From Wikipedia, the free encyclopedia
Small nucleolar RNA SNORD20
Identifiers
SymbolSNORD20
Alt. SymbolsU20
Rfam RF00217
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, snoRNA U20 (also known as SNORD20) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U20 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O- methylation of substrate RNAs. [1]

U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804. [3] [4]

References

  1. ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi: 10.1128/MCB.22.19.6663-6668.2002. PMC  134041. PMID  12215523.
  2. ^ Nicoloso M, Caizergues-Ferrer M, Michot B, Azum MC, Bachellerie JP (September 1994). "U20, a novel small nucleolar RNA, is encoded in an intron of the nucleolin gene in mammals". Molecular and Cellular Biology. 14 (9): 5766–76. doi: 10.1128/mcb.14.9.5766. PMC  359102. PMID  8065311.
  3. ^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi: 10.1016/S0092-8674(00)81308-2. PMID  8674114. S2CID  10418885.
  4. ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX  10.1.1.105.7552. doi: 10.1093/nar/gkj002. PMC  1347365. PMID  16381836.

External links


From Wikipedia, the free encyclopedia
Small nucleolar RNA SNORD20
Identifiers
SymbolSNORD20
Alt. SymbolsU20
Rfam RF00217
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, snoRNA U20 (also known as SNORD20) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U20 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O- methylation of substrate RNAs. [1]

U20 is encoded in intron 11 of the nucleolin gene in human, mouse and rat. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U1804. [3] [4]

References

  1. ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi: 10.1128/MCB.22.19.6663-6668.2002. PMC  134041. PMID  12215523.
  2. ^ Nicoloso M, Caizergues-Ferrer M, Michot B, Azum MC, Bachellerie JP (September 1994). "U20, a novel small nucleolar RNA, is encoded in an intron of the nucleolin gene in mammals". Molecular and Cellular Biology. 14 (9): 5766–76. doi: 10.1128/mcb.14.9.5766. PMC  359102. PMID  8065311.
  3. ^ Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi: 10.1016/S0092-8674(00)81308-2. PMID  8674114. S2CID  10418885.
  4. ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX  10.1.1.105.7552. doi: 10.1093/nar/gkj002. PMC  1347365. PMID  16381836.

External links



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