DNA-directed RNA polymerase II subunit RPB3 is an
enzyme that in humans is encoded by the POLR2Cgene.[5]
Function
This gene encodes the third largest subunit of
RNA polymerase II, the polymerase responsible for synthesizing messenger
RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit,
POLR2J. These two subunits form a core subassembly unit of the polymerase. A
pseudogene has been identified on chromosome 21.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9.
doi:
10.1006/geno.1994.1208.
PMID8034326.
^De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C (Jul 2003). "Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)". FEBS Lett. 547 (1–3): 15–9.
doi:
10.1016/s0014-5793(03)00659-8.
PMID12860379.
S2CID33230891.
Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606.
doi:
10.2174/138945006779025338.
PMID17168834.
Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606.
doi:
10.1006/jmbi.1996.0485.
PMID8800208.
DNA-directed RNA polymerase II subunit RPB3 is an
enzyme that in humans is encoded by the POLR2Cgene.[5]
Function
This gene encodes the third largest subunit of
RNA polymerase II, the polymerase responsible for synthesizing messenger
RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit,
POLR2J. These two subunits form a core subassembly unit of the polymerase. A
pseudogene has been identified on chromosome 21.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9.
doi:
10.1006/geno.1994.1208.
PMID8034326.
^De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova M, Floridi A, Fanciulli M, Passananti C (Jul 2003). "Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)". FEBS Lett. 547 (1–3): 15–9.
doi:
10.1016/s0014-5793(03)00659-8.
PMID12860379.
S2CID33230891.
Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606.
doi:
10.2174/138945006779025338.
PMID17168834.
Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606.
doi:
10.1006/jmbi.1996.0485.
PMID8800208.