Coiled-coil alpha-helical rod protein 1, also known as CCHCR1, is a
protein which in humans is encoded by the CCHCR1gene.[5][6][7]
Gene
The Human CCHCR1 gene is located at 6p21.33. It is also known as Coiled-Coil Alphahelical Rod Protein 1, C6orf18, Putative Gene 8 Protein, SBP, HCR (A-Helix Coiled-Coil Rod Homologue), pg8, StAR-Binding Protein, and Pg8.
Homology
Homologes for CCHCR1 are conserved through
tetrapods.
Paralogs
Orthologs
CCHCR1 has orthologs throughout vertebrates.
Distant Homologs
Homologous Domains
Phylogeny
Phylogenetic analysis with ClustalW indicated that CCHCR1
In genetically engineered mice, certain CCHCR1
polymorphisms cause upregulation of the expression of
cytokeratins 6 (
KRT6A), 16 (
KRT16) and 17 (
KRT17) and change in expression in other genes associated with terminal differentiation and formation of the
cornified cell envelope. These CCHCR1 polymorphisms may therefore be associated with a susceptibility to
psoriasis.[16] Defective functioning of CCHCR1 may lead to abnormal
keratinocyte proliferation which is a key feature of psoriasis.[17]
Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, Kainu K, Ranta S, Turpeinen U, Hämäläinen E, Jiao H, Karvonen SL, Ikonen E, Kere J, Saarialho-Kere U, Elomaa O (2007). "The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes". J. Mol. Med. 85 (6): 589–601.
doi:
10.1007/s00109-006-0155-0.
PMID17221218.
S2CID25864002.
Coiled-coil alpha-helical rod protein 1, also known as CCHCR1, is a
protein which in humans is encoded by the CCHCR1gene.[5][6][7]
Gene
The Human CCHCR1 gene is located at 6p21.33. It is also known as Coiled-Coil Alphahelical Rod Protein 1, C6orf18, Putative Gene 8 Protein, SBP, HCR (A-Helix Coiled-Coil Rod Homologue), pg8, StAR-Binding Protein, and Pg8.
Homology
Homologes for CCHCR1 are conserved through
tetrapods.
Paralogs
Orthologs
CCHCR1 has orthologs throughout vertebrates.
Distant Homologs
Homologous Domains
Phylogeny
Phylogenetic analysis with ClustalW indicated that CCHCR1
In genetically engineered mice, certain CCHCR1
polymorphisms cause upregulation of the expression of
cytokeratins 6 (
KRT6A), 16 (
KRT16) and 17 (
KRT17) and change in expression in other genes associated with terminal differentiation and formation of the
cornified cell envelope. These CCHCR1 polymorphisms may therefore be associated with a susceptibility to
psoriasis.[16] Defective functioning of CCHCR1 may lead to abnormal
keratinocyte proliferation which is a key feature of psoriasis.[17]
Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, Kainu K, Ranta S, Turpeinen U, Hämäläinen E, Jiao H, Karvonen SL, Ikonen E, Kere J, Saarialho-Kere U, Elomaa O (2007). "The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes". J. Mol. Med. 85 (6): 589–601.
doi:
10.1007/s00109-006-0155-0.
PMID17221218.
S2CID25864002.