The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a
protein that in humans is encoded by the NCOR1gene.[5][6]
NCOR1 is a transcriptional coregulatory protein which contains several
nuclear receptor interacting domains. In addition, NCOR1 appears to recruit
histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.[5][7]
Loss of function of this protein significantly increases the strength and power of mouse muscles.[8]
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is
Nuclear receptor co-repressor 2.[9]
Interactions
Nuclear receptor co-repressor 1 has been shown to
interact with:
Nagaya T, Chen KS, Fujieda M, Ohmori S, Richer JK, Horwitz KB, Lupski JR, Seo H (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2". Genomics. 59 (3): 339–41.
doi:
10.1006/geno.1998.5694.
PMID10444336.
Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95.
doi:
10.1016/S0378-1119(99)00481-3.
PMID10675041.
^Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW (August 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6.
doi:
10.1016/s0006-291x(03)01354-8.
PMID12890497.
^Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (December 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8.
PMID12460926.
^Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63.
doi:
10.1006/bbrc.1998.9799.
PMID9878542.
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a
protein that in humans is encoded by the NCOR1gene.[5][6]
NCOR1 is a transcriptional coregulatory protein which contains several
nuclear receptor interacting domains. In addition, NCOR1 appears to recruit
histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the downregulation of gene expression.[5][7]
Loss of function of this protein significantly increases the strength and power of mouse muscles.[8]
Family
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is
Nuclear receptor co-repressor 2.[9]
Interactions
Nuclear receptor co-repressor 1 has been shown to
interact with:
Nagaya T, Chen KS, Fujieda M, Ohmori S, Richer JK, Horwitz KB, Lupski JR, Seo H (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2". Genomics. 59 (3): 339–41.
doi:
10.1006/geno.1998.5694.
PMID10444336.
Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95.
doi:
10.1016/S0378-1119(99)00481-3.
PMID10675041.
^Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW (August 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6.
doi:
10.1016/s0006-291x(03)01354-8.
PMID12890497.
^Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (December 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8.
PMID12460926.
^Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63.
doi:
10.1006/bbrc.1998.9799.
PMID9878542.