From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a
protein that in humans is encoded by the PPARGC1B
gene .
[5]
[6]
[7]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000155846 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000033871 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002).
"Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus" . Diabetologia . 44 (12): 2220–6.
doi :
10.1007/s001250100032 .
PMID
11793024 .
^ Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002).
"The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha" . J Biol Chem . 277 (16): 13918–25.
doi :
10.1074/jbc.M201134200 .
PMID
11854298 .
^
"Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta" .
Further reading
Handschin C, Spiegelman BM (2007).
"Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism" . Endocr. Rev . 27 (7): 728–35.
doi :
10.1210/er.2006-0037 .
PMID
17018837 .
Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics . 62 (1): 98–102.
doi :
10.1006/geno.1999.5977 .
PMID
10585775 .
Knutti D, Kaul A, Kralli A (2000).
"A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen" . Mol. Cell. Biol . 20 (7): 2411–22.
doi :
10.1128/MCB.20.7.2411-2422.2000 .
PMC
85422 .
PMID
10713165 .
Lin J, Puigserver P, Donovan J, et al. (2002).
"Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor" . J. Biol. Chem . 277 (3): 1645–8.
doi :
10.1074/jbc.C100631200 .
PMID
11733490 .
Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians". Diabetologia . 45 (4): 602–3, author reply 604.
doi :
10.1007/s00125-002-0783-z .
PMID
12032643 .
Hara K, Tobe K, Okada T, et al. (2003).
"A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes" . Diabetologia . 45 (5): 740–3.
doi :
10.1007/s00125-002-0803-z .
PMID
12107756 .
Huss JM, Kopp RP, Kelly DP (2002).
"Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha" . J. Biol. Chem . 277 (43): 40265–74.
doi :
10.1074/jbc.M206324200 .
PMID
12181319 .
Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochem. Biophys. Res. Commun . 299 (5): 872–9.
doi :
10.1016/S0006-291X(02)02753-5 .
PMID
12470660 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Shiraki T, Sakai N, Kanaya E, Jingami H (2003).
"Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state" . J. Biol. Chem . 278 (13): 11344–50.
doi :
10.1074/jbc.M212859200 .
PMID
12551939 .
Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance". Biochem. Biophys. Res. Commun . 301 (2): 578–82.
doi :
10.1016/S0006-291X(03)00014-7 .
PMID
12565902 .
Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003).
"Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo" . Biochem. J . 373 (Pt 1): 155–65.
doi :
10.1042/BJ20030200 .
PMC
1223480 .
PMID
12678921 .
Patti ME, Butte AJ, Crunkhorn S, et al. (2003).
"Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1" . Proc. Natl. Acad. Sci. U.S.A . 100 (14): 8466–71.
Bibcode :
2003PNAS..100.8466P .
doi :
10.1073/pnas.1032913100 .
PMC
166252 .
PMID
12832613 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Ling C, Poulsen P, Carlsson E, et al. (2004).
"Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins" . J. Clin. Invest . 114 (10): 1518–26.
doi :
10.1172/JCI21889 .
PMC
525741 .
PMID
15546003 .
Andersen G, Wegner L, Yanagisawa K, et al. (2006).
"Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity" . J. Med. Genet . 42 (5): 402–7.
doi :
10.1136/jmg.2004.026278 .
PMC
1736055 .
PMID
15863669 .
Staiger H, Staiger K, Haas C, et al. (2005).
"Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro" . Diabetologia . 48 (10): 2115–8.
doi :
10.1007/s00125-005-1895-z .
PMID
16132959 .
Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006).
"Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer" . Carcinogenesis . 27 (11): 2201–8.
doi :
10.1093/carcin/bgl067 .
PMID
16704985 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .