Nuclear receptor coactivator 6 is a
protein that in humans is encoded by the NCOA6gene.[5][6][7]
Function
The
protein encoded by this gene is a
transcriptionalcoactivator that can interact with
nuclearhormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and
steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors,
histone acetyltransferases, and
methyltransferases.[7]
^Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J (November 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. 1 (13): 948–58.
PMID14638867.
Carney JP, McKnight C, VanEpps S, Kelley MR (1995). "Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats". Gene. 155 (2): 289–92.
doi:
10.1016/0378-1119(94)00758-K.
PMID7536696.
Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer". Cancer Res. 56 (15): 3446–50.
PMID8758910.
Espejo F, Green M, Preece NE, Assa-Munt N (2003). "NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation". J. Biomol. NMR. 23 (2): 151–2.
doi:
10.1023/A:1016398403157.
PMID12153040.
S2CID40822239.
Nuclear receptor coactivator 6 is a
protein that in humans is encoded by the NCOA6gene.[5][6][7]
Function
The
protein encoded by this gene is a
transcriptionalcoactivator that can interact with
nuclearhormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and
steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors,
histone acetyltransferases, and
methyltransferases.[7]
^Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J (November 2003). "Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation". Mol. Cancer Res. 1 (13): 948–58.
PMID14638867.
Carney JP, McKnight C, VanEpps S, Kelley MR (1995). "Random rapid amplification of cDNA ends (RRACE) allows for cloning of multiple novel human cDNA fragments containing (CAG)n repeats". Gene. 155 (2): 289–92.
doi:
10.1016/0378-1119(94)00758-K.
PMID7536696.
Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS (1996). "Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer". Cancer Res. 56 (15): 3446–50.
PMID8758910.
Espejo F, Green M, Preece NE, Assa-Munt N (2003). "NMR assignment of human ASC2, a self contained protein interaction domain involved in apoptosis and inflammation". J. Biomol. NMR. 23 (2): 151–2.
doi:
10.1023/A:1016398403157.
PMID12153040.
S2CID40822239.