From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
RCOR1
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
2IW5 ,
2UXN ,
2UXX ,
2V1D ,
2X0L ,
2XAF ,
2XAG ,
2XAH ,
2XAJ ,
2XAQ ,
2XAS ,
2Y48 ,
3ZMS ,
3ZMT ,
3ZMU ,
3ZMV ,
3ZMZ ,
3ZN0 ,
3ZN1 ,
4BAY ,
4KUM ,
4UV8 ,
4UV9 ,
4UVA ,
4UVB ,
4UVC ,
4UXN ,
5L3D ,
5L3B ,
5L3C ,
4XBF
Identifiers
Aliases
RCOR1 , COREST, RCOR, REST corepressor 1External IDs
OMIM :
607675
MGI :
106340
HomoloGene :
32246
GeneCards :
RCOR1
Wikidata
REST corepressor 1 also known as CoREST is a
protein that in humans is encoded by the RCOR1
gene .
[5]
[6]
Function
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining
neural cell
differentiation . The encoded protein binds to the
C-terminal domain of
REST (repressor element-1 silencing transcription factor).
[6]
Interactions
RCOR1 has been shown to
interact with
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000089902 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000037896 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999).
"CoREST: a functional corepressor required for regulation of neural-specific gene expression" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9873–8.
Bibcode :
1999PNAS...96.9873A .
doi :
10.1073/pnas.96.17.9873 .
PMC
22303 .
PMID
10449787 .
^
a
b
"Entrez Gene: RCOR1 REST corepressor 1" .
^
a
b
c
d Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002).
"A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7420–5.
Bibcode :
2002PNAS...99.7420H .
doi :
10.1073/pnas.112008599 .
PMC
124246 .
PMID
12032298 .
^
a
b You A, Tong JK, Grozinger CM, Schreiber SL (February 2001).
"CoREST is an integral component of the CoREST- human histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1454–8.
Bibcode :
2001PNAS...98.1454Y .
doi :
10.1073/pnas.98.4.1454 .
PMC
29278 .
PMID
11171972 .
^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun . 322 (2): 601–8.
doi :
10.1016/j.bbrc.2004.07.163 .
PMID
15325272 .
Further reading
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994).
"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 1 (5): 223–9.
doi :
10.1093/dnares/1.5.223 .
PMID
7584044 .
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13.
doi :
10.1006/abio.1996.0138 .
PMID
8619474 .
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997).
"Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8.
doi :
10.1101/gr.7.4.353 .
PMC
139146 .
PMID
9110174 .
Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T (2000).
"The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex" . J. Biol. Chem . 275 (13): 9461–7.
doi :
10.1074/jbc.275.13.9461 .
PMID
10734093 .
Hartley JL, Temple GF, Brasch MA (2000).
"DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001).
"Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1" . J. Biol. Chem . 276 (9): 6817–24.
doi :
10.1074/jbc.M007372200 .
PMID
11102443 .
You A, Tong JK, Grozinger CM, Schreiber SL (2001).
"CoREST is an integral component of the CoREST- human histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1454–8.
Bibcode :
2001PNAS...98.1454Y .
doi :
10.1073/pnas.98.4.1454 .
PMC
29278 .
PMID
11171972 .
Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G (2001).
"Regulation of neuronal traits by a novel transcriptional complex" . Neuron . 31 (3): 353–65.
doi :
10.1016/S0896-6273(01)00371-3 .
PMID
11516394 .
Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (2002).
"A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7420–5.
Bibcode :
2002PNAS...99.7420H .
doi :
10.1073/pnas.112008599 .
PMC
124246 .
PMID
12032298 .
Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G (2002).
"REST repression of neuronal genes requires components of the hSWI.SNF complex" . J. Biol. Chem . 277 (43): 41038–45.
doi :
10.1074/jbc.M205691200 .
PMID
12192000 .
Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes". Science . 298 (5599): 1747–52.
Bibcode :
2002Sci...298.1747L .
CiteSeerX
10.1.1.136.7131 .
doi :
10.1126/science.1076469 .
PMID
12399542 .
S2CID
13507921 .
Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003).
"A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes" . J. Biol. Chem . 278 (9): 7234–9.
doi :
10.1074/jbc.M208992200 .
PMID
12493763 .
Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun . 322 (2): 601–8.
doi :
10.1016/j.bbrc.2004.07.163 .
PMID
15325272 .
Gu H, Liang Y, Mandel G, Roizman B (2005).
"Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells" . Proc. Natl. Acad. Sci. U.S.A . 102 (21): 7571–6.
Bibcode :
2005PNAS..102.7571G .
doi :
10.1073/pnas.0502658102 .
PMC
1140450 .
PMID
15897453 .
Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature . 437 (7057): 432–5.
Bibcode :
2005Natur.437..432L .
doi :
10.1038/nature04021 .
PMID
16079794 .
S2CID
4396351 .
Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005).
"Regulation of LSD1 histone demethylase activity by its associated factors" . Mol. Cell . 19 (6): 857–64.
doi :
10.1016/j.molcel.2005.08.027 .
PMID
16140033 .
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006).
"Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6.
Bibcode :
2006PNAS..103.5391N .
doi :
10.1073/pnas.0507066103 .
PMC
1459365 .
PMID
16565220 .
PDB gallery
2iw5 : STRUCTURAL BASIS FOR COREST-DEPENDENT DEMETHYLATION OF NUCLEOSOMES BY THE HUMAN LSD1 HISTONE DEMETHYLASE
2uxn : STRUCTURAL BASIS OF HISTONE DEMETHYLATION BY LSD1 REVEALED BY SUICIDE INACTIVATION
2v1d : STRUCTURAL BASIS OF LSD1-COREST SELECTIVITY IN HISTONE H3 RECOGNITION
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .