3-Iodo-L-tyrosine
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Names | |
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IUPAC name
(2S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
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Other names
Monoiodotyrosine; MIT
[1]
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Identifiers | |
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3D model (
JSmol)
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ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.000.677 |
MeSH | Monoiodotyrosine |
PubChem
CID
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C9H10INO3 | |
Molar mass | 307.087 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones which is derived from iodination of tyrosine at the meta-position of the benzene ring. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle. Two units can combine to form 3,3'-diiodothyronine.
3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase. [2]
3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels. [3]
3-Iodo-L-tyrosine
| |
Names | |
---|---|
IUPAC name
(2S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
| |
Other names
Monoiodotyrosine; MIT
[1]
| |
Identifiers | |
| |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.000.677 |
MeSH | Monoiodotyrosine |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C9H10INO3 | |
Molar mass | 307.087 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3-Iodotyrosine is an intermediate in the synthesis of thyroid hormones which is derived from iodination of tyrosine at the meta-position of the benzene ring. One unit can combine with diiodotyrosine to form triiodothyronine, as occurs in the colloid of the thyroid follicle. Two units can combine to form 3,3'-diiodothyronine.
3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase. [2]
3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels. [3]