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Hang on, At least sharks produce urea and they are aquatic. — Preceding unsigned comment added by 213.167.138.65 ( talk) 09:56, 9 July 2004 (UTC)
Someone changed the 'Lab use' section to say that it is used in concentrations up to 10M (rather than 6M, as it said before). I don't think that you can actually make a solution of urea that concentrated, at least under mild conditions. I'll leave it as I don't know for sure, but this may be inaccurate. ike9898 14:17, Feb 2, 2005 (UTC)
Sigma-Aldrich is one of the largest chemical supply companies for labs, I have just looked in their catalog and they have 8M Urea avalible. http://www.sigmaaldrich.com/Brands/Sigma/Sigma_General_Catalog.html Onco p53 19:48, 2 Feb 2005 (UTC)
How did the early chemists isolate urea from urine or other biological samples? — Preceding unsigned comment added by 129.78.64.104 ( talk) 01:49, 9 March 2005 (UTC)
I would like to comment on this page from the perspective of a high school student taking a biology course. This article on urea is very informative about the composition and alternative uses of urea, but I frankly am totally lost as to what urea actually does in its natural function. Perhaps some description of its function, or at least something clearer (in case I simply cannot discern its function)would add to the usefulness of this article. — Preceding unsigned comment added by 199.216.81.20 ( talk) 19:26, 2 November 2005 (UTC)
In the discovery section, I see the following:
"Although Rouelle was attempting to prepare ammonium cyanate, he inadvertently disproved the theory that the chemicals of living organisms are fundamentally different from inanimate matter by forming Urea, thus starting the discipline of organic chemistry."
Is this about Rouelle or Woehler? I am vaguely familiar with Woehler's story, and this seems like a small typo, but I'd like someone more authorative to make the call. — Preceding unsigned comment added by Jormundgard ( talk • contribs) 05:36, 18 December 2005 (UTC)
Sweat contains how much urea normally, please ? -- 213.7.155.164 11:46, 12 January 2006 (UTC)
I may be wrong, but I was comparing the definition for urea on wikipedia with the definition in my copy of Merriam-Webster's Medical Desk Dictionary and I found that the chemical formula in my dictionary did not agree with the chemical formula in the wikipedia definition. My dictionary says that the chemical formula of the nitrogenous compound in urea is: CH4N2O
I'm curious Which is correct. — Preceding unsigned comment added by 209.237.14.150 ( talk) 10:21, 14 April 2006 (UTC)
Can someone provide some better Ka and Kb data? Based on Google, I have found people ( 1 2) saying the Kb is -- Cowbert 23:37, 25 April 2006 (UTC)
I have just edited the Physiological Diagnosis subsection in the Medical Use section.... But I actually think that it should all be moved/incorporated into the blood urea nitrogen entry. It seems to me that the Urea entry should mostly focus on the chemical urea and not on the medical/physiological issues.
I would favor having only the following line under the Physiological Diagnosis subheading:
See blood urea nitrogen ("BUN") for a commonly performed urea test, and marker of renal function. DanLevy 19:46, 14 May 2006 (UTC)
I believe the pKa value of 0.18 for urea is incorrect; this is the value for the acylium ion of urea (a much more acidic species). The lower the pKa the more acidic. Since the pH of 10% water solution of urea is 7.2, I don't think urea is acidic(Merck Index, 12th edition). — Preceding unsigned comment added by 129.89.22.169 ( talk) 17:56, 23 May 2006 (UTC)
I do not know if urea is also produced as pills (or pellets), but the vast majority of commercially produced urea is produced as prills. Prills are prepared by letting small droplets of molten urea fall in high prilltowers. During the fall the droplets solidify, giving round particles of generally 1.4 - 2.0 mm size. — Preceding unsigned comment added by 213.84.153.69 ( talk) 08:02, 9 June 2006 (UTC)
Is it really true that urea is added to cigarettes for flavor? — Preceding unsigned comment added by 70.17.129.239 ( talk) 00:29, 13 June 2006 (UTC)
I was looking for scientific explanation about how and what for urea is used by microorgnisms in soil. — Preceding unsigned comment added by Merhamforal ( talk • contribs) 12:15, 17 June 2006 (UTC)
yeah...me too..can somobody help me with our investigatory project? it's isolation of urea from urine...but we really dont know how...=) do you have any idea? — Preceding unsigned comment added by 203.177.217.198 ( talk) 07:13, 29 July 2006 (UTC)
There is a contradiction between the entries on Sweating and Urea. I hope this is the right place to post this. This is my first comment.
The article on Sweating states that "Sweating (also called perspiration or sometimes transpiration) is the production and evaporation of a watery fluid, consisting mainly of sodium chloride (commonly known as salt) and urea in solution, that is secreted by the sweat glands in the skin of mammals."
The article on Urea states: "Many researchers used to believe that a small amount of urea was excreted (along with sodium chloride and water) in human sweat. However that was proved wrong when Dr. M. Falk determined at RC Institute that only sodium chloride and water are excreted from sweat.”
I don't know for sure which is correct but sweat either contains urea or it does not. Whoever wrote the paragraph at the article on Urea seems certain that sweat does not contain urea while the article on Sweating states that it does.
I have left this same comment at both articles on Urea and Sweating. — Preceding unsigned comment added by Mcgayhey ( talk • contribs) 23:28, 29 September 2006 (UTC)
Being born with mild ichtiosis the "snake skin" disease? I can attest that the only topical cream that works for me is 25% Urea. It accually allows the scales to slough off like normal skin does. When you have ichtiosis you apparently don't shed dead skin easily and don't sweat. Also you can become overheated very easily. It is strange that I actually get overheated & almost sweat when wearing the urea lotion. I wonder if this has anything to do with the prior article on whether or not urea is actually excreted in sweat considering that I don't sweat. Do you think it is a difficiency of urea in my body? —Preceding unsigned comment added by 75.130.102.58 ( talk) 01:50, 16 February 2009 (UTC)
Urea certainly works well on dry, cracked skin caused by severe athletes foot. I have been using a balm containing 25% urea for several days now, and there is a very noticable difference in my condition. What used to be hard, callous-like skin that was prone to cracking has now become soft, pliable, pink, and healthy looking! Masha Allaah! — Preceding unsigned comment added by 65.60.143.142 ( talk) 04:44, 30 September 2006 (UTC)
please add information on urine urea nitrogen (a medical lab result based on protein catobilic rate). when someone types in UUN, a link should appear to this or another urea page. when someone types in urine urea nitrogen, a redirect to somewhere should appear. maybe urine urea nitrogen should be its own article or stub. — Preceding unsigned comment added by Tkjazzer ( talk • contribs) 19:40, 11 October 2006 (UTC)
When i asked about buying urea from a company, they told me that the nitrogen it contained is over 46% (it might be the purity?!). I'm just wondering, how do they change the nitrogen content in urea? Or i've misunderstood something? tks~ — Preceding unsigned comment added by 219.80.238.184 ( talk) 04:07, 16 October 2006 (UTC)
No one can change the nitrogen content in Urea, if they did, it wouldn't be Urea. The nitrogen content gives a relative purity of the Urea you are purchasing, because it is produced from ammonia (NH3, and thus the nitrogen) and CO2 (current cheapest commercial production process). See Ullman's Encyclopedia of Industrial Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, a whole chapter on Urea. Biotechscientist ( talk) 23:44, 14 July 2011 (UTC)
Urea is the first organic compound synthetically made from an inorganic salt. It has historical significance. -- Kupirijo 05:15, 1 December 2006 (UTC)
I don't have enough knowledge of this area to write an authoritative overview, but I feel it should be mentioned, especially as urea is a widely used fertilizer and the highest in nitrogen. Something on eutrophication of rivers, lakes and seas would be appropriate. Richard001 21:10, 30 January 2007 (UTC)
The article provides some specific information about the solubility of urea without giving a source. The values were out by at least a factor of 10 (probably g/L rather than g/100mL), which I have corrected by knocking off the last zero, but I don't know where the numbers come from in the first place and if they are accurate. Does anyone else know? dmcg026 10:01, 15 August 2007 (UTC)
According to the OECD the solubility of urea is 1080g/L and it's dead wrong. The value is more like 9 M. Reference Wang et. al. 2009 "Aqueous Solubility Prediction Based on Weighted Atom Type Counts and Solvent Accessible Surface Areas". They did experimental validation and it fits with what I have on my bench right now. Structurebiologist ( talk) 14:17, 6 August 2013 (UTC)
1080g/L is equivalent to 8.7 Moles/L if you assume combined volume of urea and water do not reduce after mixing (and this it normally true for highly soluble compounds) Therfore, 1080 g/l is consistent with 9 M/l Trurle ( talk) 03:35, 21 December 2017 (UTC)
On H-bonds in Urea, thats why high solb. — Preceding unsigned comment added by 58.107.233.180 ( talk) 15:24, 15 August 2007 (UTC)
There is a serious error in the diagram of the urea molecule at the top of the article. It doesn't show the carbon atom. Nigelrg ( talk) 16:55, 29 July 2015 (UTC)
Hi. I just did a slop-job of an edit on the physiology section. I just went there to look up a quick tidbit and it was just...strange. So I did what I could. I couldn't find good solid references on the web, so I'm afraid I didn't cite any, but below are a couple that are good starts (uncitable, but good explanations for the uninitiated). Also, I'm afraid my language is a bit dense. However, it's got to be better than what was there before, and at least I've got mad internal links. Can't spend time on it, I'm afraid. Here's my encouraging, "Woo-hoo!" to whoever will spend the time on it that it deserves:)
Links that might help whoever wants to work on it: http://www.acbrown.com/renal/OutLoop.htm AND http://www2.kumc.edu/ki/physiology/course/seven/7_4.htm (btw, I haven't really looked through them so I'm not completely endorsing them) A0900 06:46, 30 October 2007 (UTC)
I believe there has been research that has shown that a high urea load is actually not in and of itself dangerous. More to the point, I think there's been a paper that's shown that urea just SIGNALS that something else is wonky and needs to be removed from the blood (mostly likely ammonia). I believe the experiment done was actually dumping a whole bunch of urea into pts' blood to see what would happen and answer was essentially nada. Or maybe this is just one of those, "I heard it in rounds and it isn't actually true" things. There are a TON of uncited "facts" on this page. Anyone dealing with this, would you please check on this particular "fact" that someone's listed? IF you find otherwise (i.e., that urea actually is a problem) then perhaps a mention of dialysis would be warrented? A0900 06:46, 30 October 2007 (UTC)
There's no reference whatsoever to the Urine Therapy page, which is sad. Regardless of its effectiveness or medicinal reputation, it should be mentioned. Furthermore, drugs that are derived from urine (Premarin for example) are not mentioned either in this wiki. Why not? 24.247.170.144 ( talk) 16:36, 29 July 2008 (UTC)
The usual definition of organic chemistry requires carbon-hydrogen bonds. Urea does not have even one C-H bond (all of its bonds are heavily polar, in fact), so why does everyone seem to call it an organic compound? I would argue that it isn't. At the very least, we should mention in the article that its organic-ness is somewhat debatable, though I am not sure how to word such a statement. Stonemason89 ( talk) 01:47, 8 September 2008 (UTC)
Traditionally Inorganic Chemistry has been used to describe metal compounds, these compounds include the bridge in the periodic table (e.g. Si is a metal). I understand the definition of the CH bonds and it is 100% accurate, but more often than not, if there is carbon and no metals present it is organic. If there is carbon and metals, it is organometallic. So I am with Benjah on the organic, because nitrogen is not a metal. Biotechscientist ( talk) 00:05, 15 July 2011 (UTC)
The provided pKa and pKb values are not possible - in a water solution pKa + pKb is 14. Presently, the provided values are pKb = 13.8 and pKa = 26.9, which is logically impossible. Unfortunately I don't have any better values to add. Anyone? Annelie Skoog ( talk) 19:50, 1 December 2008 (UTC)
I changed the pKa value to 0.18, since the pKb value seems reasonable. With these values, urea will be an uncharged compound under all physiological conditions. An additional comment: since urea theoretically should/could be diprotonic, it should be possible to define pKb 1 and 2, as well as pKa 1 and 2.
Annelie Skoog ( talk) 20:20, 1 December 2008 (UTC)
Ok, "in a water solution pKa + pKb is 14", this is correct, but remember this is a relative logarithmic scale centered at pH 7 for the first proton to go off of water, and one based on an ideal solution in thermodyanamics. pKa's can exist below 0 and above 14, what this means is in the case of pKa's below 0, there are very few hydroxyl's ions present in solution (to a certain degree that is estimated by the logarithmic pH scale (e.g. the log of negative number is not zero, and you are quantifying the number of protons with the log scale). To measure the pKa's of these in solution, you have to more often than not use organic solvents, hydrochloric acid has a pKa of like -3, what this means is at pH -3, half of the molecules are charged, and the other half are protonated (definition of pKa). If you are interested in learning more about this, look up superacids. The oxygen on Urea will become protonated in accordance with its pKa of 0.2 at pH's comparable on the pH logarithmic scale (e.g. the lower you get in pH the more the protons stick to the oxygens). On the other end of the scale, many protons require extreme basic conditions to be removed, as is the case with the pKa of 26.9 (the amine (e.g. NH2) protons on Urea). In this case there are very few protons free in solution on the same logarithmic pH scale that would allow the NH2 to become NH-. Hope this helps, I find that many entry level people still struggle with this even after a few college chemistry courses. Acid-Base equilibria if you can conquer it (and have good teachers) will help explain many erroneous things that occur day to day in laboratories. Biotechscientist ( talk) 02:42, 8 July 2011 (UTC)
FK1954 is correct: The pKa of 0.1-0.2 is for the conjugate acid of urea H(O=C(NH2)2)+ (likely protonated on the oxygen, not one of the nitrogens, to maximize resonance stability). This value corresponds to the pKb of urea itself. Recall that pkA + pkB = 14 is true for a conjugate base/conjugate acid pair, such as A-/HA or A/HA+. So 0.2 (for HA+) + 13.8 (for A) = 14. Reengler ( talk) 14:49, 26 April 2016 (UTC)
I think that IUPAC name is wrong. It will be better if you could change it from aminomethanamide to diaminomethanal. -- Qweeer ( talk) 07:10, 14 March 2009 (UTC)
I just checked. The Preferred IUPAC name is the retained name urea, while the systematic name is carbonic diamide. See Rule C-971 of the 1979 recommendations and Chapter 6, Sect 66, September, 2004 P-66.1.5.1.1.1 of Preferred names in the nomenclature of organic compounds.
Ben ( talk) 14:20, 14 March 2009 (UTC)
I changed it to Urea, as per Physchim62 above. End of discussion! Chris ( talk) 09:13, 4 June 2010 (UTC)
70.171.235.197 ( talk) 04:31, 1 July 2009 (UTC)Urea Nitrate should not be listed as a powerful, high explosive. Its power and velocity only resemble ammonium nitrate. 70.171.235.197 ( talk) 04:31, 1 July 2009 (UTC)
In the ammonia page, this same problem appeared a few weeks ago, it is here, and I see that it has occurred before (top discussion topic, 2007), was corrected, and seems to have re-appeared. The solubilities given must be off by an order of magnitude. Is there a bot that is doing this? Perhaps the numbers are referenced to a data table, but the units are not? Does anyone have information on this? Gaedheal ( talk) 00:09, 25 February 2010 (UTC)
The figures currently listed on the page are more accurate (51g/100 mL~8.6M). 108 g is like 17.8M, and I have seen in three separate instances 10M Urea precipitating out of solution at 2-8°C. Our lab has been working with high concentration Urea solutions (4-8M Urea) for about a year, and we are at sea level to remove any atmospheric pressure issues. Our associates have made literally hundreds of these solutions Biotechscientist ( talk) 23:58, 14 July 2011 (UTC)
Under "Uses": "Urea is also used in many multi-component solid fertilizer formulations."
and then, a few sentences later:
"Urea is not compatible with other fertilizers."
They can't both be right, can they ? Eregli bob ( talk) 17:39, 12 May 2010 (UTC)
The mp of Urea is listed as 132.7–135 °C. Having 4 significant figures in the first term and not the second doesn't make any sense. It should either read 132.7-135.0 or 133-135. I'm going to change it to the latter. —Preceding unsigned comment added by Robertblankenship ( talk • contribs) 03:35, 20 September 2010 (UTC)
If my son is looking up urea on the internet do I need to be concerned that he is doing something illegal . . . like making meth? — Preceding unsigned comment added by 24.112.120.186 ( talk) 03:00, 30 May 2011 (UTC)
Citation number 1 was for a search. However, this search has presumably expired long ago, and so you cannot access the information any more. Someone should remove it, and I think that whoever put it there should try to find where he got the information from, and find a better citation. 120.151.249.12 ( talk) 21:03, 19 April 2012 (UTC)
I removed the side remark from the introduction that urea produces ammonia in the presence of water or water vapor, as I believe this reaction does not occur spontaneously to a significant degree at room temperature, without a catalyst such as the enzyme urease produced by many soil microorganisms. It is for this reason that urease inhibitors are sometimes added to urea fertilizer. See article on ammonia volatilization from urea. I think discussions of conditions under which urea undergoes hydrolysis, and ways of catalyzing or inhibiting it, might be appropriate elsewhere in the article, but are too specialized for the introduction. CharlesHBennett ( talk) 14:23, 18 April 2013 (UTC)
The article makes the statement that urea breaks down in water to form ammonia, and this is why old urine smells worse. I believe that this is due to the action of bacteria. I can't find a single source saying if or how fast urea breaks down in plain water. The merck says it breaks down when heated in water but gives no more information. 50.133.241.236 ( talk) 22:16, 18 August 2013 (UTC)
Given the Wohler reaction, ammonium cyanate should probably redirect to this page, but I'm not savvy enough to make a redirect. Could someone help out? Magic9mushroom ( talk) 12:41, 17 July 2014 (UTC)
I wholly disagree. Not being a chemistry expert, urea has a formula of CO(NH2)2 or (NH2)2CO (depending on source) with a different physical structure from ammonium cyanate (NH4OCN). Yes, they have same atom count and elements used, but are isomers. See https://en.wikibooks.org/wiki/Organic_Chemistry/Foundational_concepts_of_organic_chemistry/History_of_organic_chemistry
Per Note 1) the sentence "Ammonium cyanate is urea." is false since ammonium cyanate (NH4OCN), is an inorganic salt, and urea ((NH2)2CO), is a biological compound. Why have a note attached saying the sentence is false? Why not just explain ammonium cyanate and its relationship to urea?
I have never seen a Wikipedia article have a (sub-)Note stating a sentence is not correct. Seems like a senior editor missed this.
Is Wikipedia simply for advanced scientists or for general readers trying to comprehend science? Bcwilmot ( talk) 02:58, 14 December 2015 (UTC)
The comment(s) below were originally left at Talk:Urea/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
Comment(s) | Press [show] to view → |
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Hmm Urea is important molecule in body, yet article is lacking in many details.
Phgao 16:00, 15 August 2007 (UTC)
I agree Urea is of top importance. It should also be noted that this article simply jumps into the the kidney's physiological functions in a very confusing manner. The article starts out really well however. Most people will not understand the way the section on human beings physiology is written. Three sentences in it finally says the word "renal" which means nothing to many people. Also it is written like something from a source not cited. Red flag. —Preceding unsigned comment added by Carnyland ( talk • contribs) 06:58, 22 April 2009 (UTC) I think that the diagram of the urea molecule shown on the upper right of the article is in error: the left branch should be -NH2 instead of -N2H. I think -N2H is impossible anyway. Isn't this simply an error in the diagram? -Michaelmartens — Preceding unsigned comment added by Michaelmartens ( talk • contribs) 20:34, 10 February 2011 (UTC) |
Last edited at 20:35, 10 February 2011 (UTC). Substituted at 09:44, 30 April 2016 (UTC)
"It forms ions and salts known as ureates." should be added, I think, but the only source I could find is https://nl.wikipedia.org/wiki/zouten "het ureaat-ion". Formula: (NH3)2CO2+
Simon de Danser ( talk) 20:44, 25 November 2020 (UTC)
As of 20220203, the three displayed structures are not equivalent. The line drawing is C2H4N2O, while the two 3d drawings and correct formula are CH4N2O. 178.200.120.156 ( talk) 20:28, 3 February 2022 (UTC)
In the Agriculture sub-section of Uses, at the very end, there is the following quote: "Another technology is the conversion of urea into derivatives, such as formaldehyde, which degrades into ammonia at a pace matching plants' nutritional requirements." I feel like this could use a bit of cleaning up, as if urea is converted into formaldehyde, which contains no nitrogen, it cannot degrade into ammonia, which does contain nitrogen. It's possible this is talking about some sort of salt of urea and formaldehyde, or some other side reaction that happens in the soil to add nitrogen to formaldehyde, or possibly about the process of cleaving urea into ammonia and formaldehyde, but I'm not familiar enough with the chemistry of this to make corrections. As it is, it doesn't sound correct. Lumberjane Lilly ( talk) 21:17, 3 June 2022 (UTC)
"As large quantities of carbon dioxide are produced during the ammonia manufacturing process as a byproduct of burning hydrocarbons to generate heat"
This isn't correct. The CO2 comes primarily from the cracking of methane in the steam reforming process.
Step 1 (steam reforming): H2O + CH4 -> 3H2 + CO
Step 2 (shift reaction): H2O + CO -> CO2 + H2
The reformer is heated by burning hydrocarbons (methane), but the flue gas (including "CO2 byproduct of burning") is vented to atmosphere.
The CO2 in the syngas (coming out of the shift reactor) is the source of the CO2 for urea production. At one plant I've worked at, amines were used to extract the CO2 from the syngas for use in urea production.
NotAnExpert89 ( talk) 13:07, 24 June 2023 (UTC)
The third paragraph of the first section of the article says that urea is "neither acidic nor alkaline", but in the Properties/Reaction section, it says that urea is basic. Which is it, please? Cladist ( talk) 23:37, 29 August 2023 (UTC)
according to VSEPR theory, should the nitrogen in urea be trigonal pyramaidal? 67.160.97.30 ( talk) 01:30, 15 December 2023 (UTC)
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Hang on, At least sharks produce urea and they are aquatic. — Preceding unsigned comment added by 213.167.138.65 ( talk) 09:56, 9 July 2004 (UTC)
Someone changed the 'Lab use' section to say that it is used in concentrations up to 10M (rather than 6M, as it said before). I don't think that you can actually make a solution of urea that concentrated, at least under mild conditions. I'll leave it as I don't know for sure, but this may be inaccurate. ike9898 14:17, Feb 2, 2005 (UTC)
Sigma-Aldrich is one of the largest chemical supply companies for labs, I have just looked in their catalog and they have 8M Urea avalible. http://www.sigmaaldrich.com/Brands/Sigma/Sigma_General_Catalog.html Onco p53 19:48, 2 Feb 2005 (UTC)
How did the early chemists isolate urea from urine or other biological samples? — Preceding unsigned comment added by 129.78.64.104 ( talk) 01:49, 9 March 2005 (UTC)
I would like to comment on this page from the perspective of a high school student taking a biology course. This article on urea is very informative about the composition and alternative uses of urea, but I frankly am totally lost as to what urea actually does in its natural function. Perhaps some description of its function, or at least something clearer (in case I simply cannot discern its function)would add to the usefulness of this article. — Preceding unsigned comment added by 199.216.81.20 ( talk) 19:26, 2 November 2005 (UTC)
In the discovery section, I see the following:
"Although Rouelle was attempting to prepare ammonium cyanate, he inadvertently disproved the theory that the chemicals of living organisms are fundamentally different from inanimate matter by forming Urea, thus starting the discipline of organic chemistry."
Is this about Rouelle or Woehler? I am vaguely familiar with Woehler's story, and this seems like a small typo, but I'd like someone more authorative to make the call. — Preceding unsigned comment added by Jormundgard ( talk • contribs) 05:36, 18 December 2005 (UTC)
Sweat contains how much urea normally, please ? -- 213.7.155.164 11:46, 12 January 2006 (UTC)
I may be wrong, but I was comparing the definition for urea on wikipedia with the definition in my copy of Merriam-Webster's Medical Desk Dictionary and I found that the chemical formula in my dictionary did not agree with the chemical formula in the wikipedia definition. My dictionary says that the chemical formula of the nitrogenous compound in urea is: CH4N2O
I'm curious Which is correct. — Preceding unsigned comment added by 209.237.14.150 ( talk) 10:21, 14 April 2006 (UTC)
Can someone provide some better Ka and Kb data? Based on Google, I have found people ( 1 2) saying the Kb is -- Cowbert 23:37, 25 April 2006 (UTC)
I have just edited the Physiological Diagnosis subsection in the Medical Use section.... But I actually think that it should all be moved/incorporated into the blood urea nitrogen entry. It seems to me that the Urea entry should mostly focus on the chemical urea and not on the medical/physiological issues.
I would favor having only the following line under the Physiological Diagnosis subheading:
See blood urea nitrogen ("BUN") for a commonly performed urea test, and marker of renal function. DanLevy 19:46, 14 May 2006 (UTC)
I believe the pKa value of 0.18 for urea is incorrect; this is the value for the acylium ion of urea (a much more acidic species). The lower the pKa the more acidic. Since the pH of 10% water solution of urea is 7.2, I don't think urea is acidic(Merck Index, 12th edition). — Preceding unsigned comment added by 129.89.22.169 ( talk) 17:56, 23 May 2006 (UTC)
I do not know if urea is also produced as pills (or pellets), but the vast majority of commercially produced urea is produced as prills. Prills are prepared by letting small droplets of molten urea fall in high prilltowers. During the fall the droplets solidify, giving round particles of generally 1.4 - 2.0 mm size. — Preceding unsigned comment added by 213.84.153.69 ( talk) 08:02, 9 June 2006 (UTC)
Is it really true that urea is added to cigarettes for flavor? — Preceding unsigned comment added by 70.17.129.239 ( talk) 00:29, 13 June 2006 (UTC)
I was looking for scientific explanation about how and what for urea is used by microorgnisms in soil. — Preceding unsigned comment added by Merhamforal ( talk • contribs) 12:15, 17 June 2006 (UTC)
yeah...me too..can somobody help me with our investigatory project? it's isolation of urea from urine...but we really dont know how...=) do you have any idea? — Preceding unsigned comment added by 203.177.217.198 ( talk) 07:13, 29 July 2006 (UTC)
There is a contradiction between the entries on Sweating and Urea. I hope this is the right place to post this. This is my first comment.
The article on Sweating states that "Sweating (also called perspiration or sometimes transpiration) is the production and evaporation of a watery fluid, consisting mainly of sodium chloride (commonly known as salt) and urea in solution, that is secreted by the sweat glands in the skin of mammals."
The article on Urea states: "Many researchers used to believe that a small amount of urea was excreted (along with sodium chloride and water) in human sweat. However that was proved wrong when Dr. M. Falk determined at RC Institute that only sodium chloride and water are excreted from sweat.”
I don't know for sure which is correct but sweat either contains urea or it does not. Whoever wrote the paragraph at the article on Urea seems certain that sweat does not contain urea while the article on Sweating states that it does.
I have left this same comment at both articles on Urea and Sweating. — Preceding unsigned comment added by Mcgayhey ( talk • contribs) 23:28, 29 September 2006 (UTC)
Being born with mild ichtiosis the "snake skin" disease? I can attest that the only topical cream that works for me is 25% Urea. It accually allows the scales to slough off like normal skin does. When you have ichtiosis you apparently don't shed dead skin easily and don't sweat. Also you can become overheated very easily. It is strange that I actually get overheated & almost sweat when wearing the urea lotion. I wonder if this has anything to do with the prior article on whether or not urea is actually excreted in sweat considering that I don't sweat. Do you think it is a difficiency of urea in my body? —Preceding unsigned comment added by 75.130.102.58 ( talk) 01:50, 16 February 2009 (UTC)
Urea certainly works well on dry, cracked skin caused by severe athletes foot. I have been using a balm containing 25% urea for several days now, and there is a very noticable difference in my condition. What used to be hard, callous-like skin that was prone to cracking has now become soft, pliable, pink, and healthy looking! Masha Allaah! — Preceding unsigned comment added by 65.60.143.142 ( talk) 04:44, 30 September 2006 (UTC)
please add information on urine urea nitrogen (a medical lab result based on protein catobilic rate). when someone types in UUN, a link should appear to this or another urea page. when someone types in urine urea nitrogen, a redirect to somewhere should appear. maybe urine urea nitrogen should be its own article or stub. — Preceding unsigned comment added by Tkjazzer ( talk • contribs) 19:40, 11 October 2006 (UTC)
When i asked about buying urea from a company, they told me that the nitrogen it contained is over 46% (it might be the purity?!). I'm just wondering, how do they change the nitrogen content in urea? Or i've misunderstood something? tks~ — Preceding unsigned comment added by 219.80.238.184 ( talk) 04:07, 16 October 2006 (UTC)
No one can change the nitrogen content in Urea, if they did, it wouldn't be Urea. The nitrogen content gives a relative purity of the Urea you are purchasing, because it is produced from ammonia (NH3, and thus the nitrogen) and CO2 (current cheapest commercial production process). See Ullman's Encyclopedia of Industrial Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, a whole chapter on Urea. Biotechscientist ( talk) 23:44, 14 July 2011 (UTC)
Urea is the first organic compound synthetically made from an inorganic salt. It has historical significance. -- Kupirijo 05:15, 1 December 2006 (UTC)
I don't have enough knowledge of this area to write an authoritative overview, but I feel it should be mentioned, especially as urea is a widely used fertilizer and the highest in nitrogen. Something on eutrophication of rivers, lakes and seas would be appropriate. Richard001 21:10, 30 January 2007 (UTC)
The article provides some specific information about the solubility of urea without giving a source. The values were out by at least a factor of 10 (probably g/L rather than g/100mL), which I have corrected by knocking off the last zero, but I don't know where the numbers come from in the first place and if they are accurate. Does anyone else know? dmcg026 10:01, 15 August 2007 (UTC)
According to the OECD the solubility of urea is 1080g/L and it's dead wrong. The value is more like 9 M. Reference Wang et. al. 2009 "Aqueous Solubility Prediction Based on Weighted Atom Type Counts and Solvent Accessible Surface Areas". They did experimental validation and it fits with what I have on my bench right now. Structurebiologist ( talk) 14:17, 6 August 2013 (UTC)
1080g/L is equivalent to 8.7 Moles/L if you assume combined volume of urea and water do not reduce after mixing (and this it normally true for highly soluble compounds) Therfore, 1080 g/l is consistent with 9 M/l Trurle ( talk) 03:35, 21 December 2017 (UTC)
On H-bonds in Urea, thats why high solb. — Preceding unsigned comment added by 58.107.233.180 ( talk) 15:24, 15 August 2007 (UTC)
There is a serious error in the diagram of the urea molecule at the top of the article. It doesn't show the carbon atom. Nigelrg ( talk) 16:55, 29 July 2015 (UTC)
Hi. I just did a slop-job of an edit on the physiology section. I just went there to look up a quick tidbit and it was just...strange. So I did what I could. I couldn't find good solid references on the web, so I'm afraid I didn't cite any, but below are a couple that are good starts (uncitable, but good explanations for the uninitiated). Also, I'm afraid my language is a bit dense. However, it's got to be better than what was there before, and at least I've got mad internal links. Can't spend time on it, I'm afraid. Here's my encouraging, "Woo-hoo!" to whoever will spend the time on it that it deserves:)
Links that might help whoever wants to work on it: http://www.acbrown.com/renal/OutLoop.htm AND http://www2.kumc.edu/ki/physiology/course/seven/7_4.htm (btw, I haven't really looked through them so I'm not completely endorsing them) A0900 06:46, 30 October 2007 (UTC)
I believe there has been research that has shown that a high urea load is actually not in and of itself dangerous. More to the point, I think there's been a paper that's shown that urea just SIGNALS that something else is wonky and needs to be removed from the blood (mostly likely ammonia). I believe the experiment done was actually dumping a whole bunch of urea into pts' blood to see what would happen and answer was essentially nada. Or maybe this is just one of those, "I heard it in rounds and it isn't actually true" things. There are a TON of uncited "facts" on this page. Anyone dealing with this, would you please check on this particular "fact" that someone's listed? IF you find otherwise (i.e., that urea actually is a problem) then perhaps a mention of dialysis would be warrented? A0900 06:46, 30 October 2007 (UTC)
There's no reference whatsoever to the Urine Therapy page, which is sad. Regardless of its effectiveness or medicinal reputation, it should be mentioned. Furthermore, drugs that are derived from urine (Premarin for example) are not mentioned either in this wiki. Why not? 24.247.170.144 ( talk) 16:36, 29 July 2008 (UTC)
The usual definition of organic chemistry requires carbon-hydrogen bonds. Urea does not have even one C-H bond (all of its bonds are heavily polar, in fact), so why does everyone seem to call it an organic compound? I would argue that it isn't. At the very least, we should mention in the article that its organic-ness is somewhat debatable, though I am not sure how to word such a statement. Stonemason89 ( talk) 01:47, 8 September 2008 (UTC)
Traditionally Inorganic Chemistry has been used to describe metal compounds, these compounds include the bridge in the periodic table (e.g. Si is a metal). I understand the definition of the CH bonds and it is 100% accurate, but more often than not, if there is carbon and no metals present it is organic. If there is carbon and metals, it is organometallic. So I am with Benjah on the organic, because nitrogen is not a metal. Biotechscientist ( talk) 00:05, 15 July 2011 (UTC)
The provided pKa and pKb values are not possible - in a water solution pKa + pKb is 14. Presently, the provided values are pKb = 13.8 and pKa = 26.9, which is logically impossible. Unfortunately I don't have any better values to add. Anyone? Annelie Skoog ( talk) 19:50, 1 December 2008 (UTC)
I changed the pKa value to 0.18, since the pKb value seems reasonable. With these values, urea will be an uncharged compound under all physiological conditions. An additional comment: since urea theoretically should/could be diprotonic, it should be possible to define pKb 1 and 2, as well as pKa 1 and 2.
Annelie Skoog ( talk) 20:20, 1 December 2008 (UTC)
Ok, "in a water solution pKa + pKb is 14", this is correct, but remember this is a relative logarithmic scale centered at pH 7 for the first proton to go off of water, and one based on an ideal solution in thermodyanamics. pKa's can exist below 0 and above 14, what this means is in the case of pKa's below 0, there are very few hydroxyl's ions present in solution (to a certain degree that is estimated by the logarithmic pH scale (e.g. the log of negative number is not zero, and you are quantifying the number of protons with the log scale). To measure the pKa's of these in solution, you have to more often than not use organic solvents, hydrochloric acid has a pKa of like -3, what this means is at pH -3, half of the molecules are charged, and the other half are protonated (definition of pKa). If you are interested in learning more about this, look up superacids. The oxygen on Urea will become protonated in accordance with its pKa of 0.2 at pH's comparable on the pH logarithmic scale (e.g. the lower you get in pH the more the protons stick to the oxygens). On the other end of the scale, many protons require extreme basic conditions to be removed, as is the case with the pKa of 26.9 (the amine (e.g. NH2) protons on Urea). In this case there are very few protons free in solution on the same logarithmic pH scale that would allow the NH2 to become NH-. Hope this helps, I find that many entry level people still struggle with this even after a few college chemistry courses. Acid-Base equilibria if you can conquer it (and have good teachers) will help explain many erroneous things that occur day to day in laboratories. Biotechscientist ( talk) 02:42, 8 July 2011 (UTC)
FK1954 is correct: The pKa of 0.1-0.2 is for the conjugate acid of urea H(O=C(NH2)2)+ (likely protonated on the oxygen, not one of the nitrogens, to maximize resonance stability). This value corresponds to the pKb of urea itself. Recall that pkA + pkB = 14 is true for a conjugate base/conjugate acid pair, such as A-/HA or A/HA+. So 0.2 (for HA+) + 13.8 (for A) = 14. Reengler ( talk) 14:49, 26 April 2016 (UTC)
I think that IUPAC name is wrong. It will be better if you could change it from aminomethanamide to diaminomethanal. -- Qweeer ( talk) 07:10, 14 March 2009 (UTC)
I just checked. The Preferred IUPAC name is the retained name urea, while the systematic name is carbonic diamide. See Rule C-971 of the 1979 recommendations and Chapter 6, Sect 66, September, 2004 P-66.1.5.1.1.1 of Preferred names in the nomenclature of organic compounds.
Ben ( talk) 14:20, 14 March 2009 (UTC)
I changed it to Urea, as per Physchim62 above. End of discussion! Chris ( talk) 09:13, 4 June 2010 (UTC)
70.171.235.197 ( talk) 04:31, 1 July 2009 (UTC)Urea Nitrate should not be listed as a powerful, high explosive. Its power and velocity only resemble ammonium nitrate. 70.171.235.197 ( talk) 04:31, 1 July 2009 (UTC)
In the ammonia page, this same problem appeared a few weeks ago, it is here, and I see that it has occurred before (top discussion topic, 2007), was corrected, and seems to have re-appeared. The solubilities given must be off by an order of magnitude. Is there a bot that is doing this? Perhaps the numbers are referenced to a data table, but the units are not? Does anyone have information on this? Gaedheal ( talk) 00:09, 25 February 2010 (UTC)
The figures currently listed on the page are more accurate (51g/100 mL~8.6M). 108 g is like 17.8M, and I have seen in three separate instances 10M Urea precipitating out of solution at 2-8°C. Our lab has been working with high concentration Urea solutions (4-8M Urea) for about a year, and we are at sea level to remove any atmospheric pressure issues. Our associates have made literally hundreds of these solutions Biotechscientist ( talk) 23:58, 14 July 2011 (UTC)
Under "Uses": "Urea is also used in many multi-component solid fertilizer formulations."
and then, a few sentences later:
"Urea is not compatible with other fertilizers."
They can't both be right, can they ? Eregli bob ( talk) 17:39, 12 May 2010 (UTC)
The mp of Urea is listed as 132.7–135 °C. Having 4 significant figures in the first term and not the second doesn't make any sense. It should either read 132.7-135.0 or 133-135. I'm going to change it to the latter. —Preceding unsigned comment added by Robertblankenship ( talk • contribs) 03:35, 20 September 2010 (UTC)
If my son is looking up urea on the internet do I need to be concerned that he is doing something illegal . . . like making meth? — Preceding unsigned comment added by 24.112.120.186 ( talk) 03:00, 30 May 2011 (UTC)
Citation number 1 was for a search. However, this search has presumably expired long ago, and so you cannot access the information any more. Someone should remove it, and I think that whoever put it there should try to find where he got the information from, and find a better citation. 120.151.249.12 ( talk) 21:03, 19 April 2012 (UTC)
I removed the side remark from the introduction that urea produces ammonia in the presence of water or water vapor, as I believe this reaction does not occur spontaneously to a significant degree at room temperature, without a catalyst such as the enzyme urease produced by many soil microorganisms. It is for this reason that urease inhibitors are sometimes added to urea fertilizer. See article on ammonia volatilization from urea. I think discussions of conditions under which urea undergoes hydrolysis, and ways of catalyzing or inhibiting it, might be appropriate elsewhere in the article, but are too specialized for the introduction. CharlesHBennett ( talk) 14:23, 18 April 2013 (UTC)
The article makes the statement that urea breaks down in water to form ammonia, and this is why old urine smells worse. I believe that this is due to the action of bacteria. I can't find a single source saying if or how fast urea breaks down in plain water. The merck says it breaks down when heated in water but gives no more information. 50.133.241.236 ( talk) 22:16, 18 August 2013 (UTC)
Given the Wohler reaction, ammonium cyanate should probably redirect to this page, but I'm not savvy enough to make a redirect. Could someone help out? Magic9mushroom ( talk) 12:41, 17 July 2014 (UTC)
I wholly disagree. Not being a chemistry expert, urea has a formula of CO(NH2)2 or (NH2)2CO (depending on source) with a different physical structure from ammonium cyanate (NH4OCN). Yes, they have same atom count and elements used, but are isomers. See https://en.wikibooks.org/wiki/Organic_Chemistry/Foundational_concepts_of_organic_chemistry/History_of_organic_chemistry
Per Note 1) the sentence "Ammonium cyanate is urea." is false since ammonium cyanate (NH4OCN), is an inorganic salt, and urea ((NH2)2CO), is a biological compound. Why have a note attached saying the sentence is false? Why not just explain ammonium cyanate and its relationship to urea?
I have never seen a Wikipedia article have a (sub-)Note stating a sentence is not correct. Seems like a senior editor missed this.
Is Wikipedia simply for advanced scientists or for general readers trying to comprehend science? Bcwilmot ( talk) 02:58, 14 December 2015 (UTC)
The comment(s) below were originally left at Talk:Urea/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
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Hmm Urea is important molecule in body, yet article is lacking in many details.
Phgao 16:00, 15 August 2007 (UTC)
I agree Urea is of top importance. It should also be noted that this article simply jumps into the the kidney's physiological functions in a very confusing manner. The article starts out really well however. Most people will not understand the way the section on human beings physiology is written. Three sentences in it finally says the word "renal" which means nothing to many people. Also it is written like something from a source not cited. Red flag. —Preceding unsigned comment added by Carnyland ( talk • contribs) 06:58, 22 April 2009 (UTC) I think that the diagram of the urea molecule shown on the upper right of the article is in error: the left branch should be -NH2 instead of -N2H. I think -N2H is impossible anyway. Isn't this simply an error in the diagram? -Michaelmartens — Preceding unsigned comment added by Michaelmartens ( talk • contribs) 20:34, 10 February 2011 (UTC) |
Last edited at 20:35, 10 February 2011 (UTC). Substituted at 09:44, 30 April 2016 (UTC)
"It forms ions and salts known as ureates." should be added, I think, but the only source I could find is https://nl.wikipedia.org/wiki/zouten "het ureaat-ion". Formula: (NH3)2CO2+
Simon de Danser ( talk) 20:44, 25 November 2020 (UTC)
As of 20220203, the three displayed structures are not equivalent. The line drawing is C2H4N2O, while the two 3d drawings and correct formula are CH4N2O. 178.200.120.156 ( talk) 20:28, 3 February 2022 (UTC)
In the Agriculture sub-section of Uses, at the very end, there is the following quote: "Another technology is the conversion of urea into derivatives, such as formaldehyde, which degrades into ammonia at a pace matching plants' nutritional requirements." I feel like this could use a bit of cleaning up, as if urea is converted into formaldehyde, which contains no nitrogen, it cannot degrade into ammonia, which does contain nitrogen. It's possible this is talking about some sort of salt of urea and formaldehyde, or some other side reaction that happens in the soil to add nitrogen to formaldehyde, or possibly about the process of cleaving urea into ammonia and formaldehyde, but I'm not familiar enough with the chemistry of this to make corrections. As it is, it doesn't sound correct. Lumberjane Lilly ( talk) 21:17, 3 June 2022 (UTC)
"As large quantities of carbon dioxide are produced during the ammonia manufacturing process as a byproduct of burning hydrocarbons to generate heat"
This isn't correct. The CO2 comes primarily from the cracking of methane in the steam reforming process.
Step 1 (steam reforming): H2O + CH4 -> 3H2 + CO
Step 2 (shift reaction): H2O + CO -> CO2 + H2
The reformer is heated by burning hydrocarbons (methane), but the flue gas (including "CO2 byproduct of burning") is vented to atmosphere.
The CO2 in the syngas (coming out of the shift reactor) is the source of the CO2 for urea production. At one plant I've worked at, amines were used to extract the CO2 from the syngas for use in urea production.
NotAnExpert89 ( talk) 13:07, 24 June 2023 (UTC)
The third paragraph of the first section of the article says that urea is "neither acidic nor alkaline", but in the Properties/Reaction section, it says that urea is basic. Which is it, please? Cladist ( talk) 23:37, 29 August 2023 (UTC)
according to VSEPR theory, should the nitrogen in urea be trigonal pyramaidal? 67.160.97.30 ( talk) 01:30, 15 December 2023 (UTC)