Radial spoke head protein 6 homolog A (RSPH6A) also known as radial spoke head-like protein 1 (RSHL1) is a
protein that in humans is encoded by the RSPH6Agene.[5][6]
Function
Radial spoke head protein 6 homolog A is similar to a sea urchin
radial spoke head protein. Radial spoke protein complexes form part of the
axoneme of eukaryotic
flagella and are located between the axoneme's outer ring of doublet
microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of
dynein and the symmetry of flagellar bending patterns.[6]
Clinical significance
The RSPH6A gene maps to a region of chromosome 19 that is linked to primary
ciliary dyskinesia-2 (CILD2).[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eriksson M, Ansved T, Anvret M, Carey N (Mar 2001). "A mammalian radial spokehead-like gene, RSHL1, at the myotonic dystrophy-1 locus". Biochem Biophys Res Commun. 281 (4): 835–41.
doi:
10.1006/bbrc.2001.4465.
PMID11237735.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Radial spoke head protein 6 homolog A (RSPH6A) also known as radial spoke head-like protein 1 (RSHL1) is a
protein that in humans is encoded by the RSPH6Agene.[5][6]
Function
Radial spoke head protein 6 homolog A is similar to a sea urchin
radial spoke head protein. Radial spoke protein complexes form part of the
axoneme of eukaryotic
flagella and are located between the axoneme's outer ring of doublet
microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of
dynein and the symmetry of flagellar bending patterns.[6]
Clinical significance
The RSPH6A gene maps to a region of chromosome 19 that is linked to primary
ciliary dyskinesia-2 (CILD2).[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eriksson M, Ansved T, Anvret M, Carey N (Mar 2001). "A mammalian radial spokehead-like gene, RSHL1, at the myotonic dystrophy-1 locus". Biochem Biophys Res Commun. 281 (4): 835–41.
doi:
10.1006/bbrc.2001.4465.
PMID11237735.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.