60S ribosomal protein L13 is a
protein that in humans is encoded by the RPL13gene.[5][6]
Function
Ribosomes, the
organelles that catalyze
protein synthesis, consist of a small
40S subunit and a large
60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the
cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in
breast carcinomas. Transcript variants derived from
alternative splicing and/or alternative
polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome.[6]
Bbc1 (Mti1p) is a protein expressed in yeasts that is thought to associate with
actin networks. Bbc1 is short for Bni1 synthetic lethal and Bee1 (
las17) complex member.[8] The alternate name, Mti1p, is short for
Myosin tail region-interacting protein.[9] Bbc1 is involved in
cytoskeletal regulation during
endocytosis.
Budding yeast Bbc1 inhibits the activator of the
Arp2/3 complex Las17 (
WASp homolog).[10] The protein also interacts with the tail of
Myosin 1 proteins.[9]
In
fission yeast, Bbc1 is considered a WIP family cytoskeletal protein. Bbc1 localizes to actin cortical patches, cell division sites, the cell tip, and the cytosol. Cells with bbc1 gene deletion are viable.[11] Bbc1 is affinity captured by the
Nebulin-family actin filament anchoring protein Cyk3[12] and the
SMARCAD1 family
ATP-dependent DNA helicase Fft3.[11][13] Bbc1 competes with
WIP homolog Vrp1 to bind the
Myosin 1 tail to regulate actin assembly at
endocytic sites.[14]
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47.
doi:
10.1139/o95-101.
PMID8722009.
Adams SM, Helps NR, Sharp MG, Brammar WJ, Walker RA, Varley JM (1993). "Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours". Hum. Mol. Genet. 1 (2): 91–6.
doi:
10.1093/hmg/1.2.91.
PMID1301162.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50.
doi:
10.1016/0378-1119(94)90433-2.
PMID7821789.
60S ribosomal protein L13 is a
protein that in humans is encoded by the RPL13gene.[5][6]
Function
Ribosomes, the
organelles that catalyze
protein synthesis, consist of a small
40S subunit and a large
60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the
cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in
breast carcinomas. Transcript variants derived from
alternative splicing and/or alternative
polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome.[6]
Bbc1 (Mti1p) is a protein expressed in yeasts that is thought to associate with
actin networks. Bbc1 is short for Bni1 synthetic lethal and Bee1 (
las17) complex member.[8] The alternate name, Mti1p, is short for
Myosin tail region-interacting protein.[9] Bbc1 is involved in
cytoskeletal regulation during
endocytosis.
Budding yeast Bbc1 inhibits the activator of the
Arp2/3 complex Las17 (
WASp homolog).[10] The protein also interacts with the tail of
Myosin 1 proteins.[9]
In
fission yeast, Bbc1 is considered a WIP family cytoskeletal protein. Bbc1 localizes to actin cortical patches, cell division sites, the cell tip, and the cytosol. Cells with bbc1 gene deletion are viable.[11] Bbc1 is affinity captured by the
Nebulin-family actin filament anchoring protein Cyk3[12] and the
SMARCAD1 family
ATP-dependent DNA helicase Fft3.[11][13] Bbc1 competes with
WIP homolog Vrp1 to bind the
Myosin 1 tail to regulate actin assembly at
endocytic sites.[14]
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47.
doi:
10.1139/o95-101.
PMID8722009.
Adams SM, Helps NR, Sharp MG, Brammar WJ, Walker RA, Varley JM (1993). "Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours". Hum. Mol. Genet. 1 (2): 91–6.
doi:
10.1093/hmg/1.2.91.
PMID1301162.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50.
doi:
10.1016/0378-1119(94)90433-2.
PMID7821789.