Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a
protein that in humans is encoded by the EIF1AXgene.[5][6][7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small
40S ribosomal subunit to the
5' cap of messenger RNAs.[7]
Function
eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal
A-site, in a manner similar to the functionally related bacterial counterpart
IF1.[8]
Clinical significance
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[9] eIF1A is mutated in
thyroid cancers.[10]
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,
Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID16189514.
S2CID4427026.
Kim S, Kim GJ, Miyoshi H, Moon SH, Ahn SE, Lee JH, Lee HJ, Cha KY, Chung HM (Aug 2007). "Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems". Stem Cells and Development. 16 (4): 537–45.
doi:
10.1089/scd.2006.0088.
PMID17784828.
External links
Overview of all the structural information available in the
PDB for
UniProt: P47813 (Eukaryotic translation initiation factor 1A, X-chromosoma) at the
PDBe-KB.
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a
protein that in humans is encoded by the EIF1AXgene.[5][6][7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small
40S ribosomal subunit to the
5' cap of messenger RNAs.[7]
Function
eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal
A-site, in a manner similar to the functionally related bacterial counterpart
IF1.[8]
Clinical significance
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[9] eIF1A is mutated in
thyroid cancers.[10]
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,
Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID16189514.
S2CID4427026.
Kim S, Kim GJ, Miyoshi H, Moon SH, Ahn SE, Lee JH, Lee HJ, Cha KY, Chung HM (Aug 2007). "Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems". Stem Cells and Development. 16 (4): 537–45.
doi:
10.1089/scd.2006.0088.
PMID17784828.
External links
Overview of all the structural information available in the
PDB for
UniProt: P47813 (Eukaryotic translation initiation factor 1A, X-chromosoma) at the
PDBe-KB.