POLY(ADP-RIBOSE) GLYCOHYDROLASE

Poly(ADP-ribose) glycohydrolase
Poly(ADP-ribose) glycohydrolase
Identifiers
EC no.	3.2.1.143
CAS no.	9068-16-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Poly(ADP-ribose) glycohydrolase ( EC 3.2.1.143) is an enzyme.^[1]^[2] This enzyme catalyses the following chemical reaction

hydrolyses poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose

Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-ribose).

References

^ Miwa M, Sugimura T (October 1971). "Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-robose) by a calf thymus extract". The Journal of Biological Chemistry. 246 (20): 6362–4. PMID 4331388.
^ Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 272 (18): 11895–901. doi: 10.1074/jbc.272.18.11895. PMID 9115250.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases ( list) EC2 Transferases ( list) EC3 Hydrolases ( list) EC4 Lyases ( list) EC5 Isomerases ( list) EC6 Ligases ( list) EC7 Translocases ( list)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases ( list) EC2 Transferases ( list) EC3 Hydrolases ( list) EC4 Lyases ( list) EC5 Isomerases ( list) EC6 Ligases ( list) EC7 Translocases ( list)