From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14 , is an enzyme that in humans is encoded by the PPT2
gene .
[5]
[6]
[7]
Function
This gene encodes a member of the
palmitoyl protein thioesterase family. The encoded
glycosylated
lysosomal protein has
palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze
palmitate from
cysteine residues in proteins.
[5]
References
^
a
b
c
ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 GRCh38: Ensembl release 89: ENSG00000227600, ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000015474 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
"Entrez Gene: palmitoyl-protein thioesterase 2" .
^ Soyombo AA, Hofmann SL (October 1997).
"Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity" . J. Biol. Chem . 272 (43): 27456–63.
doi :
10.1074/jbc.272.43.27456 .
PMID
9341199 .
^ Soyombo AA, Yi W, Hofmann SL (March 1999). "Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3". Genomics . 56 (2): 208–16.
doi :
10.1006/geno.1998.5703 .
PMID
10051407 .
Further reading
Gupta P, Soyombo AA, Atashband A, et al. (2001).
"Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice" . Proc. Natl. Acad. Sci. U.S.A . 98 (24): 13566–71.
Bibcode :
2001PNAS...9813566G .
doi :
10.1073/pnas.251485198 .
PMC
61081 .
PMID
11717424 .
Aguado B, Campbell RD (1999).
"Characterization of a human MHC class III region gene product with S-thioesterase activity" . Biochem. J . 341 ( Pt 3) (Pt 3): 679–89.
doi :
10.1042/bj3410679 .
PMC
1220406 .
PMID
10417332 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2000).
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92.
doi :
10.1093/embo-reports/kvd058 .
PMC
1083732 .
PMID
11256614 .
Hancock DB, Eijgelsheim M, Wilk JB, et al. (2010).
"Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function" . Nat. Genet . 42 (1): 45–52.
doi :
10.1038/ng.500 .
PMC
2832852 .
PMID
20010835 .
Wiemann S, Weil B, Wellenreuther R, et al. (2001).
"Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35.
doi :
10.1101/gr.GR1547R .
PMC
311072 .
PMID
11230166 .
Calero G, Gupta P, Nonato MC, et al. (2003).
"The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2" . J. Biol. Chem . 278 (39): 37957–64.
doi :
10.1074/jbc.M301225200 .
PMID
12855696 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11.
Bibcode :
2003Natur.425..805M .
doi :
10.1038/nature02055 .
PMID
14574404 .
Barcellos LF, May SL, Ramsay PP, et al. (2009). Roopenian DC (ed.).
"High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions" . PLOS Genet . 5 (10): e1000696.
doi :
10.1371/journal.pgen.1000696 .
PMC
2758598 .
PMID
19851445 .
McKinnon E, Morahan G, Nolan D, et al. (2009).
"Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach" . Diabetes Obes Metab . 11 (Suppl 1): 92–100.
doi :
10.1111/j.1463-1326.2008.01009.x .
PMC
2755510 .
PMID
19143821 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Xie T, Rowen L, Aguado B, et al. (2003).
"Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse" . Genome Res . 13 (12): 2621–36.
doi :
10.1101/gr.1736803 .
PMC
403804 .
PMID
14656967 .
Hartley JL, Temple GF, Brasch MA (2000).
"DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Hillman RT, Green RE, Brenner SE (2004).
"An unappreciated role for RNA surveillance" . Genome Biol . 5 (2): R8.
doi :
10.1186/gb-2004-5-2-r8 .
PMC
395752 .
PMID
14759258 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
Activity Regulation Classification Kinetics Types