From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Cytosolic acyl coenzyme A thioester hydrolase is an
enzyme that in
humans is encoded by the ACOT7
gene .
[5]
[6]
[7]
[8]
This gene encodes a member of the
acyl
coenzyme family. The encoded protein
hydrolyzes the
CoA
thioester of
palmitoyl-CoA and other long-chain
fatty acids . Decreased expression of this gene may be associated with
mesial temporal lobe epilepsy . Alternatively spliced transcript variants encoding distinct
isoforms with different
subcellular locations have been characterized.
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000097021 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028937 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem . 126 (6): 1013–9.
doi :
10.1093/oxfordjournals.jbchem.a022544 .
PMID
10578051 .
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005).
"A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases" . J Lipid Res . 46 (9): 2029–32.
doi :
10.1194/jlr.E500003-JLR200 .
PMID
16103133 .
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006).
"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs" . FASEB J . 20 (11): 1855–64.
doi :
10.1096/fj.06-6042com .
PMID
16940157 .
S2CID
501610 .
^
a
b
"Entrez Gene: ACOT7 acyl-CoA thioesterase 7" .
External links
Further reading
Yamada J (2006). "Long-chain acyl-CoA hydrolase in the brain". Amino Acids . 28 (3): 273–8.
doi :
10.1007/s00726-005-0181-1 .
PMID
15731883 .
S2CID
10678899 .
Yamada J, Kuramochi Y, Takagi M, et al. (2003). "Human brain acyl-CoA hydrolase isoforms encoded by a single gene". Biochem. Biophys. Res. Commun . 299 (1): 49–56.
doi :
10.1016/S0006-291X(02)02587-1 .
PMID
12435388 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Yang JW, Czech T, Yamada J, et al. (2005). "Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy". Amino Acids . 27 (3–4): 269–75.
doi :
10.1007/s00726-004-0138-9 .
PMID
15592755 .
S2CID
2832201 .
Gregory SG, Barlow KF, McLay KE, et al. (2006).
"The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21.
Bibcode :
2006Natur.441..315G .
doi :
10.1038/nature04727 .
PMID
16710414 .
Lim J, Hao T, Shaw C, et al. (2006).
"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14.
doi :
10.1016/j.cell.2006.03.032 .
PMID
16713569 .
S2CID
13709685 .