1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an
enzyme that in humans is encoded by the PLCB3gene.[5][6]
The gene codes for the enzyme
phospholipase C β3. The enzyme catalyzes the formation of
inositol 1,4,5-trisphosphate and
diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two
G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT (March 1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum. Mol. Genet. 3 (10): 1775–81.
doi:
10.1093/hmg/3.10.1775.
PMID7849701.
Carozzi AJ, Kriz RW, Webster C, Parker PJ (1992). "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily". Eur. J. Biochem. 210 (2): 521–9.
doi:
10.1111/j.1432-1033.1992.tb17450.x.
PMID1333955.
Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700.
doi:
10.1002/eji.1830250944.
PMID7589147.
S2CID20562627.
Lagercrantz J, Carson E, Phelan C, Grimmond S, Rosén A, Daré E, Nordenskjöld M, Hayward NK, Larsson C, Weber G (1995). "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)". Genomics. 26 (3): 467–72.
doi:
10.1016/0888-7543(95)80164-H.
PMID7607669.
Sinke RJ, Geurts van Kessel AG (1995). "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13". Genomics. 25 (2): 568–9.
doi:
10.1016/0888-7543(95)80060-Y.
PMID7789993.
Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A (1998). "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3". Biochim. Biophys. Acta. 1393 (1): 173–8.
doi:
10.1016/s0005-2760(98)00074-5.
PMID9714794.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92.
doi:
10.1159/000026336.
PMID9730685.
S2CID19529677.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74.
doi:
10.1046/j.1471-4159.1999.0731363.x.
PMID10501179.
S2CID25410140.
Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72.
doi:
10.1016/S0167-4781(00)00260-8.
PMID11118617.
Stålberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B (2001). "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene". Biochem. Biophys. Res. Commun. 281 (1): 227–31.
doi:
10.1006/bbrc.2001.4329.
PMID11178984.
Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56.
doi:
10.1016/S0303-7207(01)00383-5.
PMID11325525.
S2CID338776.
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an
enzyme that in humans is encoded by the PLCB3gene.[5][6]
The gene codes for the enzyme
phospholipase C β3. The enzyme catalyzes the formation of
inositol 1,4,5-trisphosphate and
diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two
G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT (March 1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum. Mol. Genet. 3 (10): 1775–81.
doi:
10.1093/hmg/3.10.1775.
PMID7849701.
Carozzi AJ, Kriz RW, Webster C, Parker PJ (1992). "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily". Eur. J. Biochem. 210 (2): 521–9.
doi:
10.1111/j.1432-1033.1992.tb17450.x.
PMID1333955.
Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700.
doi:
10.1002/eji.1830250944.
PMID7589147.
S2CID20562627.
Lagercrantz J, Carson E, Phelan C, Grimmond S, Rosén A, Daré E, Nordenskjöld M, Hayward NK, Larsson C, Weber G (1995). "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)". Genomics. 26 (3): 467–72.
doi:
10.1016/0888-7543(95)80164-H.
PMID7607669.
Sinke RJ, Geurts van Kessel AG (1995). "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13". Genomics. 25 (2): 568–9.
doi:
10.1016/0888-7543(95)80060-Y.
PMID7789993.
Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A (1998). "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3". Biochim. Biophys. Acta. 1393 (1): 173–8.
doi:
10.1016/s0005-2760(98)00074-5.
PMID9714794.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92.
doi:
10.1159/000026336.
PMID9730685.
S2CID19529677.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74.
doi:
10.1046/j.1471-4159.1999.0731363.x.
PMID10501179.
S2CID25410140.
Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72.
doi:
10.1016/S0167-4781(00)00260-8.
PMID11118617.
Stålberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B (2001). "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene". Biochem. Biophys. Res. Commun. 281 (1): 227–31.
doi:
10.1006/bbrc.2001.4329.
PMID11178984.
Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56.
doi:
10.1016/S0303-7207(01)00383-5.
PMID11325525.
S2CID338776.