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Clinical data | |
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Other names | MP; Methylhydroxyprogesterone; 6α-Methyl-17α-hydroxyprogesterone; 6α-Methyl-17α-hydroxypregn-4-en-3,20-dione |
Drug class | Progestin; Progestogen |
ATC code |
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Legal status | |
Legal status | |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.007.545 |
Chemical and physical data | |
Formula | C22H32O3 |
Molar mass | 344.495 g·mol−1 |
3D model ( JSmol) | |
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Medroxyprogesterone (MP), is a progestin which is not used medically. [2] [3] [4] [5] A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison. [6] Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, [6] and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone. [7]
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. [8] Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. [9] In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor. [10]
Compound | Ki | EC50 a | EC50b |
---|---|---|---|
Progesterone | 4.3 | 0.9 | 25 |
Medroxyprogesterone | 241 | 47 | 32 |
Medroxyprogesterone acetate | 1.2 | 0.6 | 0.15 |
Values are nM. a = Coactivator recruitment. b = Reporter cell line. |
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [2] [3] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position. [2] [3] The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol. [2] [3]
Medroxyprogesterone is the generic name of the drug and its INN and BAN . [2] [3] [5]
Brand Name
Meprate 10 Tablets (practo)
![]() | |
![]() | |
Clinical data | |
---|---|
Other names | MP; Methylhydroxyprogesterone; 6α-Methyl-17α-hydroxyprogesterone; 6α-Methyl-17α-hydroxypregn-4-en-3,20-dione |
Drug class | Progestin; Progestogen |
ATC code |
|
Legal status | |
Legal status | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.007.545 |
Chemical and physical data | |
Formula | C22H32O3 |
Molar mass | 344.495 g·mol−1 |
3D model ( JSmol) | |
| |
|
Medroxyprogesterone (MP), is a progestin which is not used medically. [2] [3] [4] [5] A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison. [6] Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, [6] and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone. [7]
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen. [8] Medroxyprogesterone is also notable in that it is a minor metabolite of MPA. [9] In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor. [10]
Compound | Ki | EC50 a | EC50b |
---|---|---|---|
Progesterone | 4.3 | 0.9 | 25 |
Medroxyprogesterone | 241 | 47 | 32 |
Medroxyprogesterone acetate | 1.2 | 0.6 | 0.15 |
Values are nM. a = Coactivator recruitment. b = Reporter cell line. |
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [2] [3] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position. [2] [3] The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol. [2] [3]
Medroxyprogesterone is the generic name of the drug and its INN and BAN . [2] [3] [5]
Brand Name
Meprate 10 Tablets (practo)