Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase | |||||||||
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Identifiers | |||||||||
EC no. | 3.2.1.114 | ||||||||
CAS no. | 82047-77-6 | ||||||||
Alt. names | mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known as Golgi α-mannosidase II, is an enzyme with systematic name (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase. [1] [2] [3] [4] It catalyses the hydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl- oligosaccharide Man5(GlcNAc)3.
This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked glycan processing and is inhibited by small molecule swainsonine. [5]
Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 3.2.1.114 | ||||||||
CAS no. | 82047-77-6 | ||||||||
Alt. names | mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
|
Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known as Golgi α-mannosidase II, is an enzyme with systematic name (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase. [1] [2] [3] [4] It catalyses the hydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl- oligosaccharide Man5(GlcNAc)3.
This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked glycan processing and is inhibited by small molecule swainsonine. [5]