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Clinical data | |
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Trade names | Heifermax, MGA |
Other names | MGA; MLA; MLGA; Melengesterol acetate; Methylsuperlutin; U-21240; BDH-1921; 17α-Acetoxy-16-methylene-6-methyl-6-dehydroprogesterone; 17α-Acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione |
Drug class | Progestogen; Progestin; Progestogen ester |
ATC code |
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CAS Number | |
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DrugBank | |
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KEGG | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.018.964 |
Chemical and physical data | |
Formula | C25H32O4 |
Molar mass | 396.527 g·mol−1 |
3D model ( JSmol) | |
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Melengestrol acetate (MLGA), sold under the brand names Heifermax and MGA among others, is a progestin medication which is used in animal reproduction. [1] [2] It is not approved for use in humans, and is instead used as an implantable contraceptive for captive animals in zoos and other refuges, [3] and is also used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada. [4]
MLGA is used in animal reproduction. [3] [4]
MLGA is a progestogen, and hence is an agonist of the progesterone receptor. [5] It has been found to possess 73% of the affinity of progesterone for the progesterone receptor in rhesus monkey uterus. [5]
MLGA, also known as 17α-acetoxy-16-methylene-6-dehydro-6-methylprogesterone or as 17α-acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [1] [2] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6 position, a methylene group at the C16 position, a double bond between the C6 and C7 positions, and an acetate ester at the C17α position. [1] [2] As such, it is also a derivative of 16-methylene-17α-hydroxyprogesterone acetate. MLGA is the acetate ester of melengestrol, which in contrast, has never been marketed. [1] Analogues of MLGA include other 17α-hydroxyprogesterone derivatives such as chlormadinone acetate, chlormethenmadinone acetate, cyproterone acetate, delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, methenmadinone acetate, and osaterone acetate. [1] The only structural difference between MLGA and megestrol acetate is the presence of the C16 methylene group in the former. [1]
Melengestrol acetate is the generic name of the drug and its USAN and USP . [1] [2] Melengestrol is the INN and BAN of the unesterified free alcohol form. [1] [2]
MLGA is marketed under the brand names Heifermax and MGA among others. [1] [2]
![]() | |
Clinical data | |
---|---|
Trade names | Heifermax, MGA |
Other names | MGA; MLA; MLGA; Melengesterol acetate; Methylsuperlutin; U-21240; BDH-1921; 17α-Acetoxy-16-methylene-6-methyl-6-dehydroprogesterone; 17α-Acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione |
Drug class | Progestogen; Progestin; Progestogen ester |
ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.018.964 |
Chemical and physical data | |
Formula | C25H32O4 |
Molar mass | 396.527 g·mol−1 |
3D model ( JSmol) | |
| |
|
Melengestrol acetate (MLGA), sold under the brand names Heifermax and MGA among others, is a progestin medication which is used in animal reproduction. [1] [2] It is not approved for use in humans, and is instead used as an implantable contraceptive for captive animals in zoos and other refuges, [3] and is also used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada. [4]
MLGA is used in animal reproduction. [3] [4]
MLGA is a progestogen, and hence is an agonist of the progesterone receptor. [5] It has been found to possess 73% of the affinity of progesterone for the progesterone receptor in rhesus monkey uterus. [5]
MLGA, also known as 17α-acetoxy-16-methylene-6-dehydro-6-methylprogesterone or as 17α-acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [1] [2] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6 position, a methylene group at the C16 position, a double bond between the C6 and C7 positions, and an acetate ester at the C17α position. [1] [2] As such, it is also a derivative of 16-methylene-17α-hydroxyprogesterone acetate. MLGA is the acetate ester of melengestrol, which in contrast, has never been marketed. [1] Analogues of MLGA include other 17α-hydroxyprogesterone derivatives such as chlormadinone acetate, chlormethenmadinone acetate, cyproterone acetate, delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, methenmadinone acetate, and osaterone acetate. [1] The only structural difference between MLGA and megestrol acetate is the presence of the C16 methylene group in the former. [1]
Melengestrol acetate is the generic name of the drug and its USAN and USP . [1] [2] Melengestrol is the INN and BAN of the unesterified free alcohol form. [1] [2]
MLGA is marketed under the brand names Heifermax and MGA among others. [1] [2]