Glycosyl hydrolases family 15 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Glyco_hydro_15 | ||||||||
Pfam | PF00723 | ||||||||
Pfam clan | CL0059 | ||||||||
SCOP2 | 1glm / SCOPe / SUPFAM | ||||||||
CAZy | GH15 | ||||||||
|
In molecular biology, glycoside hydrolase family 15 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. [1] [2] [3] This classification is available on the CAZy web site, [4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [6] [7] y[ _]9
Glycoside hydrolase family 15 CAZY GH_15 comprises enzymes with several known activities; glucoamylase ( EC 3.2.1.3); alpha-glucosidase ( EC 3.2.1.20); glucodextranase ( EC 3.2.1.70).
Glucoamylase (GA) catalyses the release of D-glucose from the non-reducing ends of starch and other oligo- or poly-saccharides. Studies of fungal GA have indicated 3 closely clustered acidic residues that play a role in the catalytic mechanism. [8] This region is also conserved in a recently sequenced bacterial GA. [9]
The 3D structure of the pseudo- tetrasaccharide acarbose complexed with glucoamylase II(471) from Aspergillus awamori var. X100 has been determined to 2.4 A resolution. [10] The protein belongs to the mainly alpha class, and contains 19 helices and 9 strands.
Glycosyl hydrolases family 15 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Glyco_hydro_15 | ||||||||
Pfam | PF00723 | ||||||||
Pfam clan | CL0059 | ||||||||
SCOP2 | 1glm / SCOPe / SUPFAM | ||||||||
CAZy | GH15 | ||||||||
|
In molecular biology, glycoside hydrolase family 15 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. [1] [2] [3] This classification is available on the CAZy web site, [4] [5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [6] [7] y[ _]9
Glycoside hydrolase family 15 CAZY GH_15 comprises enzymes with several known activities; glucoamylase ( EC 3.2.1.3); alpha-glucosidase ( EC 3.2.1.20); glucodextranase ( EC 3.2.1.70).
Glucoamylase (GA) catalyses the release of D-glucose from the non-reducing ends of starch and other oligo- or poly-saccharides. Studies of fungal GA have indicated 3 closely clustered acidic residues that play a role in the catalytic mechanism. [8] This region is also conserved in a recently sequenced bacterial GA. [9]
The 3D structure of the pseudo- tetrasaccharide acarbose complexed with glucoamylase II(471) from Aspergillus awamori var. X100 has been determined to 2.4 A resolution. [10] The protein belongs to the mainly alpha class, and contains 19 helices and 9 strands.