From Wikipedia, the free encyclopedia
A glycinergic agent (or drug) is a chemical which functions to directly modulate the glycine system in the body or brain. Examples include
glycine receptor agonists,
glycine receptor antagonists, and
glycine reuptake inhibitors.
See also
References
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Receptor (
ligands) |
GlyRTooltip Glycine receptor |
- Positive modulators:
Alcohols (e.g.,
brometone,
chlorobutanol (chloretone),
ethanol (alcohol),
tert-butanol (2M2P),
tribromoethanol,
trichloroethanol,
trifluoroethanol)
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Alkylbenzene sulfonate
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Anandamide
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Barbiturates (e.g.,
pentobarbital,
sodium thiopental)
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Chlormethiazole
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D12-116
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Dihydropyridines (e.g.,
nicardipine)
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Etomidate
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Ginseng constituents (e.g.,
ginsenosides (e.g.,
ginsenoside-Rf))
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Glutamic acid (glutamate)
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Ivermectin
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Ketamine
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Neuroactive steroids (e.g.,
alfaxolone,
pregnenolone (eltanolone),
pregnenolone acetate,
minaxolone,
ORG-20599)
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Nitrous oxide
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Penicillin G
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Propofol
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Tamoxifen
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Tetrahydrocannabinol
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Triclofos
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Tropeines (e.g.,
atropine,
bemesetron,
cocaine,
LY-278584,
tropisetron,
zatosetron)
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Volatiles/
gases (e.g.,
chloral hydrate,
chloroform,
desflurane,
diethyl ether (ether),
enflurane,
halothane,
isoflurane,
methoxyflurane,
sevoflurane,
toluene,
trichloroethane (methyl chloroform),
trichloroethylene)
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Xenon
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Zinc
- Antagonists:
2-Aminostrychnine
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2-Nitrostrychnine
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4-Phenyl-4-formyl-N-methylpiperidine
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αEMBTL
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Bicuculline
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Brucine
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Cacotheline
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Caffeine
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Colchicine
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Colubrine
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Cyanotriphenylborate
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Dendrobine
-
Diaboline
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Endocannabinoids (e.g.,
2-AG,
anandamide (AEA))
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Gaboxadol (THIP)
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Gelsemine
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iso-THAZ
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Isobutyric acid
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Isonipecotic acid
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Isostrychnine
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Laudanosine
-
N-Methylbicuculline
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N-Methylstrychnine
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N,N-Dimethylmuscimol
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Nipecotic acid
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Pitrazepin
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Pseudostrychnine
-
Quinolines (e.g.,
4-hydroxyquinoline,
4-hydroxyquinoline-3-carboxylic acid,
5,7-CIQA,
7-CIQ,
7-TFQ,
7-TFQA)
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RU-5135
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Sinomenine
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Strychnine
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Thiocolchicoside
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Tutin
- Negative modulators:
Amiloride
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Benzodiazepines (e.g.,
bromazepam,
clonazepam,
diazepam,
flunitrazepam,
flurazepam)
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Corymine
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Cyanotriphenylborate
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Daidzein
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Dihydropyridines (e.g.,
nicardipine,
nifedipine,
nitrendipine)
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Furosemide
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Genistein
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Ginkgo constituents (e.g.,
bilobalide,
ginkgolides (e.g.,
ginkgolide A,
ginkgolide B,
ginkgolide C,
ginkgolide J,
ginkgolide M))
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Imipramine
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NBQX
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Neuroactive steroids (e.g.,
3α-androsterone sulfate,
3β-androsterone sulfate,
deoxycorticosterone,
DHEA sulfate,
pregnenolone sulfate,
progesterone)
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Opioids (e.g.,
codeine,
dextromethorphan,
dextrorphan,
levomethadone,
levorphanol,
morphine,
oripavine,
pethidine,
thebaine)
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Picrotoxin (i.e.,
picrotin and
picrotoxinin)
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PMBA
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Riluzole
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Tropeines (e.g.,
bemesetron,
LY-278584,
tropisetron,
zatosetron)
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Verapamil
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Zinc
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NMDARTooltip N-Methyl-D-aspartate receptor | |
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Transporter (
blockers) |
GlyT1Tooltip Glycine transporter 1 | |
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GlyT2Tooltip Glycine transporter 2 | |
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