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Clinical data | |
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Other names | SH-368; Estradiol undecenoate; Estra-1,3,5(10)-triene-3,17β-diol 17β-(10-undecenoate) |
Routes of administration | Intramuscular injection |
Drug class | Estrogen; Estrogen ester |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.080.203 |
Chemical and physical data | |
Formula | C29H42O3 |
Molar mass | 438.652 g·mol−1 |
3D model ( JSmol) | |
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Estradiol undecylenate (EUe; developmental code name SH-368) [1] is an estrogen medication and estrogen ester which was never marketed. [2] It is the C17β undecenoate (undecylenate) ester of estradiol. [2] Following an intramuscular injection, EUe has a very prolonged effect, exceeding that of other estradiol esters like estradiol valerate and estradiol enanthate. [3] Due to its very long duration of action, EUe releases only subthreshold amounts of estradiol at conventional doses. [3] However, this may still be useful in menopausal hormone therapy. [3]
estradiol undecylate [...] Delestrec [...] SQ 9993 [...] estradiol undecylenate [...] SH 368
Retarded estrogens. In animal experiments it has been shown esterification at C-17 results in longer retarding effects than esterification at C-3. The optimal retarding effect (exceeding 29 days) may be obtained with the C-17 oenanthate. However, the effect exceeds the time interval of 28 days normally considered sufficient for the treatment of a female during one period and for this reason the shorter active estradiol-17-valerianate has been introduced. The estradiol undecylenate has a more protracted effect but it releases only subthreshold doses of steroid (advantage may be taken of this for the treatment of menopause).
![]() | |
Clinical data | |
---|---|
Other names | SH-368; Estradiol undecenoate; Estra-1,3,5(10)-triene-3,17β-diol 17β-(10-undecenoate) |
Routes of administration | Intramuscular injection |
Drug class | Estrogen; Estrogen ester |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.080.203 |
Chemical and physical data | |
Formula | C29H42O3 |
Molar mass | 438.652 g·mol−1 |
3D model ( JSmol) | |
| |
|
Estradiol undecylenate (EUe; developmental code name SH-368) [1] is an estrogen medication and estrogen ester which was never marketed. [2] It is the C17β undecenoate (undecylenate) ester of estradiol. [2] Following an intramuscular injection, EUe has a very prolonged effect, exceeding that of other estradiol esters like estradiol valerate and estradiol enanthate. [3] Due to its very long duration of action, EUe releases only subthreshold amounts of estradiol at conventional doses. [3] However, this may still be useful in menopausal hormone therapy. [3]
estradiol undecylate [...] Delestrec [...] SQ 9993 [...] estradiol undecylenate [...] SH 368
Retarded estrogens. In animal experiments it has been shown esterification at C-17 results in longer retarding effects than esterification at C-3. The optimal retarding effect (exceeding 29 days) may be obtained with the C-17 oenanthate. However, the effect exceeds the time interval of 28 days normally considered sufficient for the treatment of a female during one period and for this reason the shorter active estradiol-17-valerianate has been introduced. The estradiol undecylenate has a more protracted effect but it releases only subthreshold doses of steroid (advantage may be taken of this for the treatment of menopause).