pro-opiomelanocortin | |||||||
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Identifiers | |||||||
Symbol | POMC | ||||||
NCBI gene | 5443 | ||||||
HGNC | 9201 | ||||||
OMIM | 176830 | ||||||
RefSeq | NM_000939 | ||||||
UniProt | P01189 | ||||||
Other data | |||||||
Locus | Chr. 2 p23 | ||||||
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Names | |
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IUPAC name
L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
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Identifiers | |
3D model (
JSmol)
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ChemSpider | |
PubChem
CID
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Properties | |
C112H165N27O36 | |
Molar mass | 2465.705 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH), [1] [2] which in turn is a cleavage product of proopiomelanocortin (POMC). [3] Its physiological role has been investigated in various tissues, [4] [5] specifically in the central nervous system. [6] [7] [8] [9] [10]
It has been suggested to function as an insulin secretagogue in the pancreas. [11]
pro-opiomelanocortin | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | POMC | ||||||
NCBI gene | 5443 | ||||||
HGNC | 9201 | ||||||
OMIM | 176830 | ||||||
RefSeq | NM_000939 | ||||||
UniProt | P01189 | ||||||
Other data | |||||||
Locus | Chr. 2 p23 | ||||||
|
Names | |
---|---|
IUPAC name
L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
| |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
PubChem
CID
|
|
| |
| |
Properties | |
C112H165N27O36 | |
Molar mass | 2465.705 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH), [1] [2] which in turn is a cleavage product of proopiomelanocortin (POMC). [3] Its physiological role has been investigated in various tissues, [4] [5] specifically in the central nervous system. [6] [7] [8] [9] [10]
It has been suggested to function as an insulin secretagogue in the pancreas. [11]