The BartonâZard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanide under basic conditions. [1] It is named after Derek Barton and Samir Zard who first reported it in 1985. [2]
The mechanism consists of five steps:
The nitro compound may be aromatic rather than just an alkene. [3] The reaction has been used for the synthesis of polypyrroles, including porphyrins, [4] as well as dipyrromethenes such as BODIPY. [5]
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cite journal}}
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The BartonâZard reaction is a route to pyrrole derivatives via the reaction of a nitroalkene with an α-isocyanide under basic conditions. [1] It is named after Derek Barton and Samir Zard who first reported it in 1985. [2]
The mechanism consists of five steps:
The nitro compound may be aromatic rather than just an alkene. [3] The reaction has been used for the synthesis of polypyrroles, including porphyrins, [4] as well as dipyrromethenes such as BODIPY. [5]
{{
cite journal}}
: CS1 maint: DOI inactive as of March 2024 (
link)
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