De Kimpe aziridine synthesis | |
---|---|
Named after | Norbert De Kimpe |
Reaction type | Ring forming reaction |
Identifiers | |
Organic Chemistry Portal | de-kimpe-aziridine-synthesis |
The De Kimpe azirdine synthesis is a name reaction of organic chemistry, for the generation of aziridines by the reaction of α-chloroimines with nucleophiles such as hydride, [1] cyanide, or Grignard reagents. [2] [3]
The De Kimpe aziridine synthesis is suitable for both aldimines and ketimines, particularly those with two alkyl substituents on the α-carbon ( Thorpe-Ingold effect). [4]
The nucleophile attacks the imino carbon atom, forming a tetrahedral intermediate. The intermediate then undergoes an intramolecular nucleophilic substitution, with the negatively charged nitrogen atom attacking the α-carbon and having the chloride anion as the leaving group.
De Kimpe aziridine synthesis | |
---|---|
Named after | Norbert De Kimpe |
Reaction type | Ring forming reaction |
Identifiers | |
Organic Chemistry Portal | de-kimpe-aziridine-synthesis |
The De Kimpe azirdine synthesis is a name reaction of organic chemistry, for the generation of aziridines by the reaction of α-chloroimines with nucleophiles such as hydride, [1] cyanide, or Grignard reagents. [2] [3]
The De Kimpe aziridine synthesis is suitable for both aldimines and ketimines, particularly those with two alkyl substituents on the α-carbon ( Thorpe-Ingold effect). [4]
The nucleophile attacks the imino carbon atom, forming a tetrahedral intermediate. The intermediate then undergoes an intramolecular nucleophilic substitution, with the negatively charged nitrogen atom attacking the α-carbon and having the chloride anion as the leaving group.