α-L-Fucosidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() crystal structure of Thermotoga maritima α-fucosidase | |||||||||
Identifiers | |||||||||
Symbol | α | ||||||||
Pfam | PF01120 | ||||||||
Pfam clan | CL0058 | ||||||||
InterPro | IPR000933 | ||||||||
PROSITE | PDOC00324 | ||||||||
SCOP2 | 1hl9 / SCOPe / SUPFAM | ||||||||
CAZy | GH29 | ||||||||
|
α-L-fucosidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 3.2.1.51 | ||||||||
CAS no. | 9037-65-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
The enzyme α-L-fucosidase ( EC 3.2.1.51) catalyzes the following chemical reaction: an α-L-fucoside + H2O L-fucose + an alcohol
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is α-L-fucoside fucohydrolase. This enzyme is also called α-fucosidase. It participates in N-glycan degradation and glycan structure degradation.
Deficiency of this enzyme is called fucosidosis.
In CAZy, α-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.
It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children. [1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.
α-L-Fucosidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() crystal structure of Thermotoga maritima α-fucosidase | |||||||||
Identifiers | |||||||||
Symbol | α | ||||||||
Pfam | PF01120 | ||||||||
Pfam clan | CL0058 | ||||||||
InterPro | IPR000933 | ||||||||
PROSITE | PDOC00324 | ||||||||
SCOP2 | 1hl9 / SCOPe / SUPFAM | ||||||||
CAZy | GH29 | ||||||||
|
α-L-fucosidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 3.2.1.51 | ||||||||
CAS no. | 9037-65-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
The enzyme α-L-fucosidase ( EC 3.2.1.51) catalyzes the following chemical reaction: an α-L-fucoside + H2O L-fucose + an alcohol
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is α-L-fucoside fucohydrolase. This enzyme is also called α-fucosidase. It participates in N-glycan degradation and glycan structure degradation.
Deficiency of this enzyme is called fucosidosis.
In CAZy, α-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.
It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children. [1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.