1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1), or 1,2,3,4-tetrahydrophenanthren-1-one, is a
syntheticsteroid-like
compound which was reported to be the first synthetic estrogen, or the first synthetic compound identified with estrogenic activity.[1][2] It was first synthesized in 1933 by Cook et al. and was tested due to its similarity to the presumed
chemical structure of
estrone.[1][2] Upon reassessment many decades later, the compound was found to bind only weakly to the
estrogen receptors, and, unexpectedly, did not actually have
functional activity as an estrogen or
antiestrogenin vitro or in vivo.[2] It did, however, show some
androgenic and
antiandrogenic activity in vitro.[2]
1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1), or 1,2,3,4-tetrahydrophenanthren-1-one, is a
syntheticsteroid-like
compound which was reported to be the first synthetic estrogen, or the first synthetic compound identified with estrogenic activity.[1][2] It was first synthesized in 1933 by Cook et al. and was tested due to its similarity to the presumed
chemical structure of
estrone.[1][2] Upon reassessment many decades later, the compound was found to bind only weakly to the
estrogen receptors, and, unexpectedly, did not actually have
functional activity as an estrogen or
antiestrogenin vitro or in vivo.[2] It did, however, show some
androgenic and
antiandrogenic activity in vitro.[2]