From Wikipedia, the free encyclopedia
ZC45 and ZXC21
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Subgenus: Sarbecovirus
Species:
Strain:
ZC45 and ZXC21

ZC45 and ZXC21, sometimes known as the Zhoushan virus, [1] are two bat-derived strains of severe acute respiratory syndrome–related coronavirus. They were collected from least horseshoe bats (Rhinolophus pusillus) by personnel from military laboratories in the Third Military Medical University ( Chongqing, China) and the Research Institute for Medicine of Nanjing Command ( Nanjing, China) between July 2015 and February 2017 from sites in Zhoushan, Zhejiang, China, and published in 2018. These two virus strains belong to the clade of SARS-CoV-2, the virus strain that causes COVID-19, sharing 88% nucleotide identity at the scale of the complete virus genome. [2] [3]

A phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is: [4] [5]

SARS‑CoV‑2 related coronavirus

( Bat) Rc-o319, 81% to SARS-CoV-2, Rhinolophus cornutus, Iwate, Japan [6]

Bat SL-ZXC21, 88% to SARS-CoV-2, Rhinolophus pusillus, Zhoushan, Zhejiang [7]

Bat SL-ZC45, 88% to SARS-CoV-2, Rhinolophus pusillus, Zhoushan, Zhejiang [7]

Pangolin SARSr-CoV-GX, 85.3% to SARS-CoV-2, Manis javanica, smuggled from Southeast Asia [8]

Pangolin SARSr-CoV-GD, 90.1% to SARS-CoV-2, Manis javanica, smuggled from Southeast Asia [9]

Bat RshSTT182, 92.6% to SARS-CoV-2, Rhinolophus shameli, Steung Treng, Cambodia [10]

Bat RshSTT200, 92.6% to SARS-CoV-2, Rhinolophus shameli, Steung Treng, Cambodia [10]

(Bat) RacCS203, 91.5% to SARS-CoV-2, Rhinolophus acuminatus, Chachoengsao, Thailand [5]

(Bat) RmYN02, 93.3% to SARS-CoV-2, Rhinolophus malayanus, Mengla, Yunnan [11]

(Bat) RpYN06, 94.4% to SARS-CoV-2, Rhinolophus pusillus, Xishuangbanna, Yunnan [4]

(Bat) RaTG13, 96.1% to SARS-CoV-2, Rhinolophus affinis, Mojiang, Yunnan [12]

(Bat) BANAL-52, 96.8% to SARS-CoV-2, Rhinolophus malayanus, Vientiane, Laos [13]

SARS-CoV-2

SARS-CoV-1, 79% to SARS-CoV-2


References

  1. ^ 林祖偉 (2020-04-03). "肺炎疫情:新冠病毒到底哪來的?科學界的幾種說法". BBC中文. Archived from the original on 2020-07-30. Retrieved 2021-01-20.
  2. ^ Lau, Susanna K.P.; Luk, Hayes K.H.; Wong, Antonio C.P.; Li, Kenneth S.M.; Zhu, Longchao; He, Zirong; Fung, Joshua; Chan, Tony T.Y.; Fung, Kitty S.C.; Woo, Patrick C.Y. (2020). "Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2". Emerging Infectious Diseases. 26 (7): 1542–1547. doi: 10.3201/eid2607.200092. ISSN  1080-6040. PMC  7323513. PMID  32315281.
  3. ^ Zhou, Hong; Chen, Xing; Hu, Tao; Li, Juan; Song, Hao; Liu, Yanran; Wang, Peihan; Liu, Di; Yang, Jing; Holmes, Edward C.; Hughes, Alice C.; Bi, Yuhai; Shi, Weifeng (2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. Bibcode: 2020CBio...30E2196Z. doi: 10.1016/j.cub.2020.05.023. ISSN  0960-9822. PMC  7211627. PMID  32416074.
  4. ^ a b Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, et al. (August 2021). "Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses". Cell. 184 (17): 4380–4391.e14. doi: 10.1016/j.cell.2021.06.008. PMC  8188299. PMID  34147139.
  5. ^ a b Wacharapluesadee S, Tan CW, Maneeorn P, Duengkae P, Zhu F, Joyjinda Y, et al. (February 2021). "Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia". Nature Communications. 12 (1): 972. Bibcode: 2021NatCo..12..972W. doi: 10.1038/s41467-021-21240-1. PMC  7873279. PMID  33563978.
  6. ^ Murakami S, Kitamura T, Suzuki J, Sato R, Aoi T, Fujii M, et al. (December 2020). "Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan". Emerging Infectious Diseases. 26 (12): 3025–3029. doi: 10.3201/eid2612.203386. PMC  7706965. PMID  33219796.
  7. ^ a b Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi: 10.1016/j.cub.2020.05.023. PMC  7211627. PMID  32416074.
  8. ^ Lam TT, Jia N, Zhang YW, Shum MH, Jiang JF, Zhu HC, et al. (July 2020). "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins". Nature. 583 (7815): 282–285. Bibcode: 2020Natur.583..282L. doi: 10.1038/s41586-020-2169-0. PMID  32218527. S2CID  214683303.
  9. ^ Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, et al. (July 2020). "Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins". Nature. 583 (7815): 286–289. Bibcode: 2020Natur.583..286X. doi: 10.1038/s41586-020-2313-x. PMID  32380510. S2CID  256822274.
  10. ^ a b Delaune D, Hul V, Karlsson EA, Hassanin A, Ou TP, Baidaliuk A, et al. (November 2021). "A novel SARS-CoV-2 related coronavirus in bats from Cambodia". Nature Communications. 12 (1): 6563. Bibcode: 2021NatCo..12.6563D. doi: 10.1038/s41467-021-26809-4. PMC  8578604. PMID  34753934.
  11. ^ Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi: 10.1016/j.cub.2020.05.023. PMC  7211627. PMID  32416074.
  12. ^ Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273. Bibcode: 2020Natur.579..270Z. doi: 10.1038/s41586-020-2012-7. PMC  7095418. PMID  32015507.
  13. ^ Temmam S, Vongphayloth K, Baquero E, Munier S, Bonomi M, Regnault B, et al. (April 2022). "Bat coronaviruses related to SARS-CoV-2 and infectious for human cells". Nature. 604 (7905): 330–336. Bibcode: 2022Natur.604..330T. doi: 10.1038/s41586-022-04532-4. PMID  35172323. S2CID  246902858.


From Wikipedia, the free encyclopedia
ZC45 and ZXC21
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Subgenus: Sarbecovirus
Species:
Strain:
ZC45 and ZXC21

ZC45 and ZXC21, sometimes known as the Zhoushan virus, [1] are two bat-derived strains of severe acute respiratory syndrome–related coronavirus. They were collected from least horseshoe bats (Rhinolophus pusillus) by personnel from military laboratories in the Third Military Medical University ( Chongqing, China) and the Research Institute for Medicine of Nanjing Command ( Nanjing, China) between July 2015 and February 2017 from sites in Zhoushan, Zhejiang, China, and published in 2018. These two virus strains belong to the clade of SARS-CoV-2, the virus strain that causes COVID-19, sharing 88% nucleotide identity at the scale of the complete virus genome. [2] [3]

A phylogenetic tree based on whole-genome sequences of SARS-CoV-2 and related coronaviruses is: [4] [5]

SARS‑CoV‑2 related coronavirus

( Bat) Rc-o319, 81% to SARS-CoV-2, Rhinolophus cornutus, Iwate, Japan [6]

Bat SL-ZXC21, 88% to SARS-CoV-2, Rhinolophus pusillus, Zhoushan, Zhejiang [7]

Bat SL-ZC45, 88% to SARS-CoV-2, Rhinolophus pusillus, Zhoushan, Zhejiang [7]

Pangolin SARSr-CoV-GX, 85.3% to SARS-CoV-2, Manis javanica, smuggled from Southeast Asia [8]

Pangolin SARSr-CoV-GD, 90.1% to SARS-CoV-2, Manis javanica, smuggled from Southeast Asia [9]

Bat RshSTT182, 92.6% to SARS-CoV-2, Rhinolophus shameli, Steung Treng, Cambodia [10]

Bat RshSTT200, 92.6% to SARS-CoV-2, Rhinolophus shameli, Steung Treng, Cambodia [10]

(Bat) RacCS203, 91.5% to SARS-CoV-2, Rhinolophus acuminatus, Chachoengsao, Thailand [5]

(Bat) RmYN02, 93.3% to SARS-CoV-2, Rhinolophus malayanus, Mengla, Yunnan [11]

(Bat) RpYN06, 94.4% to SARS-CoV-2, Rhinolophus pusillus, Xishuangbanna, Yunnan [4]

(Bat) RaTG13, 96.1% to SARS-CoV-2, Rhinolophus affinis, Mojiang, Yunnan [12]

(Bat) BANAL-52, 96.8% to SARS-CoV-2, Rhinolophus malayanus, Vientiane, Laos [13]

SARS-CoV-2

SARS-CoV-1, 79% to SARS-CoV-2


References

  1. ^ 林祖偉 (2020-04-03). "肺炎疫情:新冠病毒到底哪來的?科學界的幾種說法". BBC中文. Archived from the original on 2020-07-30. Retrieved 2021-01-20.
  2. ^ Lau, Susanna K.P.; Luk, Hayes K.H.; Wong, Antonio C.P.; Li, Kenneth S.M.; Zhu, Longchao; He, Zirong; Fung, Joshua; Chan, Tony T.Y.; Fung, Kitty S.C.; Woo, Patrick C.Y. (2020). "Possible Bat Origin of Severe Acute Respiratory Syndrome Coronavirus 2". Emerging Infectious Diseases. 26 (7): 1542–1547. doi: 10.3201/eid2607.200092. ISSN  1080-6040. PMC  7323513. PMID  32315281.
  3. ^ Zhou, Hong; Chen, Xing; Hu, Tao; Li, Juan; Song, Hao; Liu, Yanran; Wang, Peihan; Liu, Di; Yang, Jing; Holmes, Edward C.; Hughes, Alice C.; Bi, Yuhai; Shi, Weifeng (2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. Bibcode: 2020CBio...30E2196Z. doi: 10.1016/j.cub.2020.05.023. ISSN  0960-9822. PMC  7211627. PMID  32416074.
  4. ^ a b Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, et al. (August 2021). "Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses". Cell. 184 (17): 4380–4391.e14. doi: 10.1016/j.cell.2021.06.008. PMC  8188299. PMID  34147139.
  5. ^ a b Wacharapluesadee S, Tan CW, Maneeorn P, Duengkae P, Zhu F, Joyjinda Y, et al. (February 2021). "Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia". Nature Communications. 12 (1): 972. Bibcode: 2021NatCo..12..972W. doi: 10.1038/s41467-021-21240-1. PMC  7873279. PMID  33563978.
  6. ^ Murakami S, Kitamura T, Suzuki J, Sato R, Aoi T, Fujii M, et al. (December 2020). "Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan". Emerging Infectious Diseases. 26 (12): 3025–3029. doi: 10.3201/eid2612.203386. PMC  7706965. PMID  33219796.
  7. ^ a b Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi: 10.1016/j.cub.2020.05.023. PMC  7211627. PMID  32416074.
  8. ^ Lam TT, Jia N, Zhang YW, Shum MH, Jiang JF, Zhu HC, et al. (July 2020). "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins". Nature. 583 (7815): 282–285. Bibcode: 2020Natur.583..282L. doi: 10.1038/s41586-020-2169-0. PMID  32218527. S2CID  214683303.
  9. ^ Xiao K, Zhai J, Feng Y, Zhou N, Zhang X, Zou JJ, et al. (July 2020). "Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins". Nature. 583 (7815): 286–289. Bibcode: 2020Natur.583..286X. doi: 10.1038/s41586-020-2313-x. PMID  32380510. S2CID  256822274.
  10. ^ a b Delaune D, Hul V, Karlsson EA, Hassanin A, Ou TP, Baidaliuk A, et al. (November 2021). "A novel SARS-CoV-2 related coronavirus in bats from Cambodia". Nature Communications. 12 (1): 6563. Bibcode: 2021NatCo..12.6563D. doi: 10.1038/s41467-021-26809-4. PMC  8578604. PMID  34753934.
  11. ^ Zhou H, Chen X, Hu T, Li J, Song H, Liu Y, et al. (June 2020). "A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein". Current Biology. 30 (11): 2196–2203.e3. doi: 10.1016/j.cub.2020.05.023. PMC  7211627. PMID  32416074.
  12. ^ Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273. Bibcode: 2020Natur.579..270Z. doi: 10.1038/s41586-020-2012-7. PMC  7095418. PMID  32015507.
  13. ^ Temmam S, Vongphayloth K, Baquero E, Munier S, Bonomi M, Regnault B, et al. (April 2022). "Bat coronaviruses related to SARS-CoV-2 and infectious for human cells". Nature. 604 (7905): 330–336. Bibcode: 2022Natur.604..330T. doi: 10.1038/s41586-022-04532-4. PMID  35172323. S2CID  246902858.



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