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Reverse genetics

Reverse genetics is a method in molecular genetics that is used to help understand the function of a gene by analysing the phenotypic effects of specific nucleic acid sequences after being genetically engineered. The process usually proceeds in the opposite direction to so-called forward genetic screens of classical genetics. In other words, while forward genetics seeks to find the genetic basis of a phenotype or trait, reverse genetics seeks to find what phenotypes arise as a result of particular genetic sequences. For instance, such procedures allow scientists to manipulate the genomes of influenza viruses by transferring genes between different strains. The novel genotypes of the viruses produced in this way have greatly diminished pathogenic potency but can still induce protective immunity in a host. Using this technique, vaccines can be created, as illustrated in this diagram depicting the development of an avian flu vaccine.

Diagram credit: Mouagip

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From Wikipedia, the free encyclopedia

Today's featured picture

Reverse genetics

Reverse genetics is a method in molecular genetics that is used to help understand the function of a gene by analysing the phenotypic effects of specific nucleic acid sequences after being genetically engineered. The process usually proceeds in the opposite direction to so-called forward genetic screens of classical genetics. In other words, while forward genetics seeks to find the genetic basis of a phenotype or trait, reverse genetics seeks to find what phenotypes arise as a result of particular genetic sequences. For instance, such procedures allow scientists to manipulate the genomes of influenza viruses by transferring genes between different strains. The novel genotypes of the viruses produced in this way have greatly diminished pathogenic potency but can still induce protective immunity in a host. Using this technique, vaccines can be created, as illustrated in this diagram depicting the development of an avian flu vaccine.

Diagram credit: Mouagip

Other areas of Wikipedia

  • Community portal – Bulletin board, projects, resources and activities covering a wide range of Wikipedia areas.
  • Help desk – Ask questions about using Wikipedia.
  • Local embassy – For Wikipedia-related communication in languages other than English.
  • Reference desk – Serving as virtual librarians, Wikipedia volunteers tackle your questions on a wide range of subjects.
  • Site news – Announcements, updates, articles and press releases on Wikipedia and the Wikimedia Foundation.
  • Village pump – For discussions about Wikipedia itself, including areas for technical issues and policies.

Wikipedia's sister projects

Wikipedia is hosted by the Wikimedia Foundation, a non-profit organization that also hosts a range of other projects:

Wikipedia languages


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