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CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.011.824 |
Chemical and physical data | |
Formula | C23H32N2O2S |
Molar mass | 400.58 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
Thiocarlide (or tiocarlide or isoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid. [1]
Thiocarlide has considerable anti mycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis. [2] Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.[ citation needed]
Thiocarlide was developed by a Belgian company, Continental Pharma S.A. Belgo-Canadienne in Brussels, Belgium. The head researcher was Professor N. P. Buu-Hoi, head of Continental Pharma's Research Division.[ citation needed]
Clinical data | |
---|---|
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.011.824 |
Chemical and physical data | |
Formula | C23H32N2O2S |
Molar mass | 400.58 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
Thiocarlide (or tiocarlide or isoxyl) is a thiourea drug used in the treatment of tuberculosis, inhibiting synthesis of oleic acid and tuberculostearic acid. [1]
Thiocarlide has considerable anti mycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis. [2] Isoxyl inhibits M. bovis with six hours of exposure, which is similar to isoniazid and ethionamide, two other prominent anti-TB drugs. Unlike these two drugs, however, isoxyl also partially inhibits the synthesis of fatty acids.[ citation needed]
Thiocarlide was developed by a Belgian company, Continental Pharma S.A. Belgo-Canadienne in Brussels, Belgium. The head researcher was Professor N. P. Buu-Hoi, head of Continental Pharma's Research Division.[ citation needed]