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Linezolid article. This is not a forum for general discussion of the article's subject. |
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Reporting errors |
It is not the only antibiotic that inhibits protein synthesis but it is the most efficient one. There are certain strains that cannot be inhibited by any other antibiotic. —Preceding unsigned comment added by 62.1.218.193 ( talk) 16:11, 27 September 2007 (UTC)
Are you sure that this is the only antibiotic that works by inhibiting protein synthesis? Macrolides, aminoglycosides, chloramphenicol, and tetracycline are all protein synthesis inhibitors, not just linezolid.
Streptogramins too, but these generally inhibit protein elongation, not initiation, I think
The scientific meaning of antibiotic is that it is a natural product produced by some fungi (living system). This may be then completely synthesized as the case with chloramphenicol. Actually I didn't find any literature that discussed linezolid natural production; so I prefere to categorize it as an antibacterial rather than antibiotic as in case of quinolones. — Preceding unsigned comment added by 41.34.125.138 ( talk) 22:12, 26 June 2012 (UTC)
I really think the cost of this medication is worthy of a mention. I just checked with my insurance it costs $1,209.07 for 20 600mg pills. That is over $40/pill-- K8TEK 13:43, 29 August 2006 (UTC)
re: Cost Yes, The cost is prohibitive. My insurance covered my prescription but 28 tablets was at $2000.00.re;cost
Cost is especially prohibitive if you are uninsured. Having to pay for a 30 day supply of Zyvox out of pocket cost me over $1500.
--
MathewBrooks 17:17, 20 August 2007 (UTC)
I live in Australia and am on long term treatment wity Zyvox. I am a public patient and and pay absolutely nothing. There is much to be said about our just health care system. Adrian
58.161.106.31 (
talk)
00:46, 8 January 2008 (UTC)
Do you have a reference for Canadian pharmacy costs? It's still under patent in Canada, and public formularies (such as ODB) still pay $75 for. — Preceding
unsigned comment added by
142.1.57.97 (
talk)
23:45, 30 January 2013 (UTC)
Could anyone start a section on the extent and mechanism of resistance ? Rod57 ( talk) 18:29, 5 January 2009 (UTC)
Comments to follow soon jimfbleak ( talk) 12:02, 19 May 2009 (UTC)
You obviously know what you are doing, I'll give you a while to respond before a final read and formal assessment jimfbleak ( talk) 12:43, 19 May 2009 (UTC)
I wish they were all this easy! jimfbleak ( talk) 14:47, 19 May 2009 (UTC)
What does the paragraph starting with "In 2009, Pfizer paid $2.3 billion and entered a corporate integrity agreement to settle charges that it had misbranded and illegally promoted four drugs, and caused false claims to be submitted to government healthcare programs. . ." have to do with linezolid? NOTHING. It's editorializing. — Preceding unsigned comment added by Oirudleahcim ( talk • contribs) 02:12, 25 October 2015 (UTC)
FA review text
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---|
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Nearly 250 million dollars in retail sales. Should work into the article somehow. Fvasconcellos ( t· c) 02:41, 26 July 2009 (UTC)
Staphylococcus pneumoniae is a classification mistake.streptococcos pneumoniae or diplococcus pneumoniae is the correct classification <e-mail redacted for privacy reasons> —Preceding unsigned comment added by 89.97.126.1 ( talk) 06:59, 14 September 2009 (UTC)
It's been over a year since promotion, so I'm planning to do a broad update of the article using WP:MEDRS published since then. Not likely to change much, though. Fvasconcellos ( t· c) 01:56, 18 October 2010 (UTC)
For possible use in article: http://cid.oxfordjournals.org/content/59/8/e93.full
Abstract Hypoglycemia was not previously known to be a linezolid-associated adverse reaction. A case report describing symptomatic hypoglycemia in a linezolid recipient prompted a review of the US Food and Drug Administration Adverse Event Reporting System, which demonstrated a relationship between linezolid and hypoglycemia. A warning with this information was added to the linezolid package insert.
50.0.205.237 ( talk) 16:34, 27 September 2014 (UTC)
televancin and dalbavancin are mentioned as "in development" on the page under "comparable antibiotics". televancin was approved in 2013 and dalbavancin was approved in 2014. I wonder how many other aspects of this article are out of date. — Preceding unsigned comment added by 198.49.6.225 ( talk) 08:57, 30 May 2015 (UTC)
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The section on linezolid's DDIs with "serotonergics" leading to 5HT syndrome needs to be rewritten to reflect the nuances on this topic.― Biochemistry🙴❤ 15:25, 29 December 2018 (UTC)
The last paragraph of the history section is out of date now. Tedizolid is approved (FDA, EMA) for clinical use, therefore Linezolid is no longer the only oxazolidinone available. Also, of the other listed agents in development, only radezolid appears to remain in some sort of active development (the other agents were abandoned). Baegun ( talk) 10:30, 11 January 2022 (UTC)
This is the
talk page for discussing improvements to the
Linezolid article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
![]() | Linezolid is a featured article; it (or a previous version of it) has been identified as one of the best articles produced by the Wikipedia community. Even so, if you can update or improve it, please do so. | ||||||||||||
![]() | This article appeared on Wikipedia's Main Page as Today's featured article on September 14, 2009. | ||||||||||||
| |||||||||||||
Current status: Featured article |
![]() | This article is rated FA-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||
|
|
![]() | Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Linezolid.
|
![]() | This article links to one or more target anchors that no longer exist.
Please help fix the broken anchors. You can remove this template after fixing the problems. |
Reporting errors |
It is not the only antibiotic that inhibits protein synthesis but it is the most efficient one. There are certain strains that cannot be inhibited by any other antibiotic. —Preceding unsigned comment added by 62.1.218.193 ( talk) 16:11, 27 September 2007 (UTC)
Are you sure that this is the only antibiotic that works by inhibiting protein synthesis? Macrolides, aminoglycosides, chloramphenicol, and tetracycline are all protein synthesis inhibitors, not just linezolid.
Streptogramins too, but these generally inhibit protein elongation, not initiation, I think
The scientific meaning of antibiotic is that it is a natural product produced by some fungi (living system). This may be then completely synthesized as the case with chloramphenicol. Actually I didn't find any literature that discussed linezolid natural production; so I prefere to categorize it as an antibacterial rather than antibiotic as in case of quinolones. — Preceding unsigned comment added by 41.34.125.138 ( talk) 22:12, 26 June 2012 (UTC)
I really think the cost of this medication is worthy of a mention. I just checked with my insurance it costs $1,209.07 for 20 600mg pills. That is over $40/pill-- K8TEK 13:43, 29 August 2006 (UTC)
re: Cost Yes, The cost is prohibitive. My insurance covered my prescription but 28 tablets was at $2000.00.re;cost
Cost is especially prohibitive if you are uninsured. Having to pay for a 30 day supply of Zyvox out of pocket cost me over $1500.
--
MathewBrooks 17:17, 20 August 2007 (UTC)
I live in Australia and am on long term treatment wity Zyvox. I am a public patient and and pay absolutely nothing. There is much to be said about our just health care system. Adrian
58.161.106.31 (
talk)
00:46, 8 January 2008 (UTC)
Do you have a reference for Canadian pharmacy costs? It's still under patent in Canada, and public formularies (such as ODB) still pay $75 for. — Preceding
unsigned comment added by
142.1.57.97 (
talk)
23:45, 30 January 2013 (UTC)
Could anyone start a section on the extent and mechanism of resistance ? Rod57 ( talk) 18:29, 5 January 2009 (UTC)
Comments to follow soon jimfbleak ( talk) 12:02, 19 May 2009 (UTC)
You obviously know what you are doing, I'll give you a while to respond before a final read and formal assessment jimfbleak ( talk) 12:43, 19 May 2009 (UTC)
I wish they were all this easy! jimfbleak ( talk) 14:47, 19 May 2009 (UTC)
What does the paragraph starting with "In 2009, Pfizer paid $2.3 billion and entered a corporate integrity agreement to settle charges that it had misbranded and illegally promoted four drugs, and caused false claims to be submitted to government healthcare programs. . ." have to do with linezolid? NOTHING. It's editorializing. — Preceding unsigned comment added by Oirudleahcim ( talk • contribs) 02:12, 25 October 2015 (UTC)
FA review text
|
---|
|
Nearly 250 million dollars in retail sales. Should work into the article somehow. Fvasconcellos ( t· c) 02:41, 26 July 2009 (UTC)
Staphylococcus pneumoniae is a classification mistake.streptococcos pneumoniae or diplococcus pneumoniae is the correct classification <e-mail redacted for privacy reasons> —Preceding unsigned comment added by 89.97.126.1 ( talk) 06:59, 14 September 2009 (UTC)
It's been over a year since promotion, so I'm planning to do a broad update of the article using WP:MEDRS published since then. Not likely to change much, though. Fvasconcellos ( t· c) 01:56, 18 October 2010 (UTC)
For possible use in article: http://cid.oxfordjournals.org/content/59/8/e93.full
Abstract Hypoglycemia was not previously known to be a linezolid-associated adverse reaction. A case report describing symptomatic hypoglycemia in a linezolid recipient prompted a review of the US Food and Drug Administration Adverse Event Reporting System, which demonstrated a relationship between linezolid and hypoglycemia. A warning with this information was added to the linezolid package insert.
50.0.205.237 ( talk) 16:34, 27 September 2014 (UTC)
televancin and dalbavancin are mentioned as "in development" on the page under "comparable antibiotics". televancin was approved in 2013 and dalbavancin was approved in 2014. I wonder how many other aspects of this article are out of date. — Preceding unsigned comment added by 198.49.6.225 ( talk) 08:57, 30 May 2015 (UTC)
Hello fellow Wikipedians,
I have just modified 8 external links on Linezolid. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 10:25, 16 May 2017 (UTC)
The section on linezolid's DDIs with "serotonergics" leading to 5HT syndrome needs to be rewritten to reflect the nuances on this topic.― Biochemistry🙴❤ 15:25, 29 December 2018 (UTC)
The last paragraph of the history section is out of date now. Tedizolid is approved (FDA, EMA) for clinical use, therefore Linezolid is no longer the only oxazolidinone available. Also, of the other listed agents in development, only radezolid appears to remain in some sort of active development (the other agents were abandoned). Baegun ( talk) 10:30, 11 January 2022 (UTC)