| Sphingomyelin deacylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.109 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sphingomyelin deacylase ( EC 3.5.1.109, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase. [1] [2] [3] This enzyme catalyses the following chemical reaction
- (1) an N-acyl-sphingosylphosphorylcholine + H2O a fatty acid + sphingosylphosphorylcholine;
- (2) a D-glucosyl-N-acylsphingosine + H2O a fatty acid + D-glucosyl-sphingosine
The enzyme is involved in the sphingolipid metabolism in the epidermis.
References
- ^ Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (September 2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis". The Journal of Investigative Dermatology. 115 (3): 406–13. doi: 10.1046/j.1523-1747.2000.00072.x. PMID 10951276.
- ^ Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (September 2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide". The Biochemical Journal. 350 Pt 3: 747–56. doi: 10.1042/0264-6021:3500747. PMC 1221306. PMID 10970788.
- ^ Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (March 2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis". Laboratory Investigation; A Journal of Technical Methods and Pathology. 83 (3): 397–408. doi: 10.1097/01.lab.0000059931.66821.92. PMID 12649340.
External links
- Sphingomyelin+deacylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Sphingomyelin deacylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.109 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Sphingomyelin deacylase ( EC 3.5.1.109, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase. [1] [2] [3] This enzyme catalyses the following chemical reaction
- (1) an N-acyl-sphingosylphosphorylcholine + H2O a fatty acid + sphingosylphosphorylcholine;
- (2) a D-glucosyl-N-acylsphingosine + H2O a fatty acid + D-glucosyl-sphingosine
The enzyme is involved in the sphingolipid metabolism in the epidermis.
References
- ^ Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G (September 2000). "High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis". The Journal of Investigative Dermatology. 115 (3): 406–13. doi: 10.1046/j.1523-1747.2000.00072.x. PMID 10951276.
- ^ Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G (September 2000). "The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide". The Biochemical Journal. 350 Pt 3: 747–56. doi: 10.1042/0264-6021:3500747. PMC 1221306. PMID 10970788.
- ^ Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G (March 2003). "Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis". Laboratory Investigation; A Journal of Technical Methods and Pathology. 83 (3): 397–408. doi: 10.1097/01.lab.0000059931.66821.92. PMID 12649340.
External links
- Sphingomyelin+deacylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)