Robert Fettiplace | |
|---|---|
.jpg) | |
| Born | Nottingham, England |
| Nationality | British |
| Alma mater | Cambridge University |
| Awards | Kavli Prize in Neuroscience (2018) |
| Scientific career | |
| Fields | Neurobiology |
| Institutions | University of Wisconsin–Madison |
Robert Fettiplace FRS is a British neuroscientist, and Steenbock Professor of Neural and Behavioral Sciences, at the University of Wisconsin–Madison. [1] [2]
Work
Fettiplace studied the mechanism of hearing in vertebrates. In 1976, he and Andrew Crawford developed a method of recording the electrical responses of hair cells in the isolated cochlea of reptiles. These experiments, which were the first to give extensive quantitative records from auditory receptors, showed that each hair cell is sharply tuned to a characteristic frequency and that much of the frequency selectivity in the turtle’s ear can be attributed to electrical resonance in the hair cell membrane.[ citation needed]
Later work proved that the resonant frequency was set by the density and kinetics of potassium channels, the frequency increasing with a greater number of faster channels. At least three classes of potassium channels are needed to cover the range of hearing: voltage- and calcium-activated (BK) channels, voltage-gated (Kv) channels, and inwardly rectifying channels. These channels work together with voltage-gated calcium channels to generate electrical resonance, a conclusion that was supported by mathematical reconstruction and simulations. [3] This mechanism is present in all vertebrate classes except mammals.
Another important development was the use of new methods of imaging hair cell stereociliary bundles and delivering force stimuli, providing the first demonstration of sub-micron active oscillations of the bundles. His subsequent work has focused on determining the properties, location and identity of the mechanically sensitive ion channels that transduce sound stimuli into electrical signals. [4]
Awards and honours
Fettiplace was elected a Fellow of the Royal Society (FRS) in 1990. [4] He was also elected a Fellow of American Academy of Arts and Sciences in 2012. [5] In 2018, Dr. Fettiplace shared the Kavli Prize in Neuroscience with A. James Hudspeth and Christine Petit and in 2020 also the Louisa Gross Horwitz Prize. [6]
References
- ^ "Fettiplace, Robert". Department of Neuroscience. 298. Retrieved 15 April 2019.
- ^ "Fettiplace, Robert". Neuroscience Training Program. 634. Retrieved 15 April 2019.
- ^ Wu, Y.-C; Art, J.J; Goodman, M.B; Fettiplace, R (1995). "A kinetic description of the calcium-activated potassium channel and its application to electrical tuning of hair cells". Progress in Biophysics and Molecular Biology. 63 (2): 131–58. doi: 10.1016/0079-6107(95)00002-5. PMID 7624477.
- ^
a
b
"Robert Fettiplace". London:
Royal Society. One or more of the preceding sentences may incorporate text from the royalsociety.org website where "all text published under the heading 'Biography' on Fellow profile pages is available under
Creative Commons Attribution 4.0 International License."
"Royal Society Terms, conditions and policies". Archived from the original on 20 February 2016. Retrieved 9 March 2016.
{{ cite web}}: CS1 maint: bot: original URL status unknown ( link) - ^ "Robert Fettiplace". American Academy of Arts & Sciences. 21 June 2021. Retrieved 23 June 2021.
- ^ "The Louisa Gross Horwitz Prize". Columbia University Irving Medical Center. 14 June 2018. Retrieved 14 December 2021.
| International | |
|---|---|
| National | |
| Academics | |
Robert Fettiplace | |
|---|---|
|
| |
| Born | Nottingham, England |
| Nationality | British |
| Alma mater | Cambridge University |
| Awards | Kavli Prize in Neuroscience (2018) |
| Scientific career | |
| Fields | Neurobiology |
| Institutions | University of Wisconsin–Madison |
Robert Fettiplace FRS is a British neuroscientist, and Steenbock Professor of Neural and Behavioral Sciences, at the University of Wisconsin–Madison. [1] [2]
Work
Fettiplace studied the mechanism of hearing in vertebrates. In 1976, he and Andrew Crawford developed a method of recording the electrical responses of hair cells in the isolated cochlea of reptiles. These experiments, which were the first to give extensive quantitative records from auditory receptors, showed that each hair cell is sharply tuned to a characteristic frequency and that much of the frequency selectivity in the turtle’s ear can be attributed to electrical resonance in the hair cell membrane.[ citation needed]
Later work proved that the resonant frequency was set by the density and kinetics of potassium channels, the frequency increasing with a greater number of faster channels. At least three classes of potassium channels are needed to cover the range of hearing: voltage- and calcium-activated (BK) channels, voltage-gated (Kv) channels, and inwardly rectifying channels. These channels work together with voltage-gated calcium channels to generate electrical resonance, a conclusion that was supported by mathematical reconstruction and simulations. [3] This mechanism is present in all vertebrate classes except mammals.
Another important development was the use of new methods of imaging hair cell stereociliary bundles and delivering force stimuli, providing the first demonstration of sub-micron active oscillations of the bundles. His subsequent work has focused on determining the properties, location and identity of the mechanically sensitive ion channels that transduce sound stimuli into electrical signals. [4]
Awards and honours
Fettiplace was elected a Fellow of the Royal Society (FRS) in 1990. [4] He was also elected a Fellow of American Academy of Arts and Sciences in 2012. [5] In 2018, Dr. Fettiplace shared the Kavli Prize in Neuroscience with A. James Hudspeth and Christine Petit and in 2020 also the Louisa Gross Horwitz Prize. [6]
References
- ^ "Fettiplace, Robert". Department of Neuroscience. 298. Retrieved 15 April 2019.
- ^ "Fettiplace, Robert". Neuroscience Training Program. 634. Retrieved 15 April 2019.
- ^ Wu, Y.-C; Art, J.J; Goodman, M.B; Fettiplace, R (1995). "A kinetic description of the calcium-activated potassium channel and its application to electrical tuning of hair cells". Progress in Biophysics and Molecular Biology. 63 (2): 131–58. doi: 10.1016/0079-6107(95)00002-5. PMID 7624477.
- ^
a
b
"Robert Fettiplace". London:
Royal Society. One or more of the preceding sentences may incorporate text from the royalsociety.org website where "all text published under the heading 'Biography' on Fellow profile pages is available under
Creative Commons Attribution 4.0 International License."
"Royal Society Terms, conditions and policies". Archived from the original on 20 February 2016. Retrieved 9 March 2016.
{{ cite web}}: CS1 maint: bot: original URL status unknown ( link) - ^ "Robert Fettiplace". American Academy of Arts & Sciences. 21 June 2021. Retrieved 23 June 2021.
- ^ "The Louisa Gross Horwitz Prize". Columbia University Irving Medical Center. 14 June 2018. Retrieved 14 December 2021.
| International | |
|---|---|
| National | |
| Academics | |