Azim Surani | |
---|---|
Born | 1945 (age 78–79) |
Alma mater |
Plymouth University (BSc) University of Strathclyde (MSc) University of Cambridge (PhD) |
Awards |
Gabor Medal (2001) Royal Medal (2010) Mendel Lectures (2010) Gairdner Foundation International Award (2018) [1] Mendel Medal (2022) |
Scientific career | |
Institutions | University of Cambridge |
Thesis | Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus (1975) |
Doctoral advisor | Robert Edwards |
Doctoral students | Kat Arney [2] |
Other notable students | Anne Ferguson-Smith (postdoc) [3] |
Website |
www |
Azim Surani CBE FRS FMedSci [1] (born 1945 in Kisumu, Kenya) is a Kenyan-British developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/ Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013. [4] [5]
Surani was educated at Plymouth University (BSc),[ when?] the University of Strathclyde (MSc) [6] and the University of Cambridge (PhD) where his research was supervised by Robert Edwards, who later won the Nobel Prize in Physiology or Medicine. [1] [6] [7]
Surani co-discovered mammalian genomic imprinting with Davor Solter [8] in 1984, and subsequently examined its mechanism and the functions of imprinted genes. [1] He later established the genetic basis for germ cell specification, using a single-cell analysis in mice. [1] This genetic network also initiates the unique resetting of the germline epigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency. [1] Epigenetic modifications and re-establishments of imprints then generate functional differences between parental genomes whilst aberrant imprints contribute to human disease. [1]
Surani's research is identifying key regulators of human germ line development and epigenome reprogramming, revealing differences between humans and mice attributable to their divergent pluripotent states and early postimplantation development. [1] He is also investigating transposable elements, host defence mechanisms, noncoding RNAs, and the potential for transgenerational epigenetic inheritance in mammals. [1]
Surani has received several awards for his work including the Royal Medal (2010), the Gabor Medal (2001) and the Mendel Lectures (2010).[ citation needed] He received the Canada Gairdner International Award, with Davor Solter, "For the discovery of mammalian genomic imprinting that causes parent-of-origin specific gene expression and its consequences for development and disease." [9] He won the Rosenstiel Award in 2006, with Solter and Mary Lyon, for "pioneering work on epigenetic gene regulation in mammalian embryos". [10]
"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." -- "Terms, conditions and policies | Royal Society". Archived from the original on 11 November 2016. Retrieved 30 August 2017.
{{ cite web}}
: CS1 maint: bot: original URL status unknown ( link)
Azim Surani | |
---|---|
Born | 1945 (age 78–79) |
Alma mater |
Plymouth University (BSc) University of Strathclyde (MSc) University of Cambridge (PhD) |
Awards |
Gabor Medal (2001) Royal Medal (2010) Mendel Lectures (2010) Gairdner Foundation International Award (2018) [1] Mendel Medal (2022) |
Scientific career | |
Institutions | University of Cambridge |
Thesis | Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus (1975) |
Doctoral advisor | Robert Edwards |
Doctoral students | Kat Arney [2] |
Other notable students | Anne Ferguson-Smith (postdoc) [3] |
Website |
www |
Azim Surani CBE FRS FMedSci [1] (born 1945 in Kisumu, Kenya) is a Kenyan-British developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/ Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013. [4] [5]
Surani was educated at Plymouth University (BSc),[ when?] the University of Strathclyde (MSc) [6] and the University of Cambridge (PhD) where his research was supervised by Robert Edwards, who later won the Nobel Prize in Physiology or Medicine. [1] [6] [7]
Surani co-discovered mammalian genomic imprinting with Davor Solter [8] in 1984, and subsequently examined its mechanism and the functions of imprinted genes. [1] He later established the genetic basis for germ cell specification, using a single-cell analysis in mice. [1] This genetic network also initiates the unique resetting of the germline epigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency. [1] Epigenetic modifications and re-establishments of imprints then generate functional differences between parental genomes whilst aberrant imprints contribute to human disease. [1]
Surani's research is identifying key regulators of human germ line development and epigenome reprogramming, revealing differences between humans and mice attributable to their divergent pluripotent states and early postimplantation development. [1] He is also investigating transposable elements, host defence mechanisms, noncoding RNAs, and the potential for transgenerational epigenetic inheritance in mammals. [1]
Surani has received several awards for his work including the Royal Medal (2010), the Gabor Medal (2001) and the Mendel Lectures (2010).[ citation needed] He received the Canada Gairdner International Award, with Davor Solter, "For the discovery of mammalian genomic imprinting that causes parent-of-origin specific gene expression and its consequences for development and disease." [9] He won the Rosenstiel Award in 2006, with Solter and Mary Lyon, for "pioneering work on epigenetic gene regulation in mammalian embryos". [10]
"All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." -- "Terms, conditions and policies | Royal Society". Archived from the original on 11 November 2016. Retrieved 30 August 2017.
{{ cite web}}
: CS1 maint: bot: original URL status unknown ( link)