![]() | |
Identifiers | |
---|---|
| |
PubChem CID | |
Chemical and physical data | |
Formula | C14H16N2 |
Molar mass | 212.296 g·mol−1 |
3D model ( JSmol) | |
| |
|
RS134-49 is a tetrahydropyridine derivative related to psychedelic tryptamines which acts as a 5-HT2A receptor agonist, with a 5-HT2A Ki of 11.5nM and an EC50 of 22nM. It is a biased agonist selective for activation of the Gq coupled signalling pathway with weaker activation of the β-arrestin 2 coupled pathway, but shows a more balanced profile than related compounds such as (R)-69. [1] [2]
![]() | |
Identifiers | |
---|---|
| |
PubChem CID | |
Chemical and physical data | |
Formula | C14H16N2 |
Molar mass | 212.296 g·mol−1 |
3D model ( JSmol) | |
| |
|
RS134-49 is a tetrahydropyridine derivative related to psychedelic tryptamines which acts as a 5-HT2A receptor agonist, with a 5-HT2A Ki of 11.5nM and an EC50 of 22nM. It is a biased agonist selective for activation of the Gq coupled signalling pathway with weaker activation of the β-arrestin 2 coupled pathway, but shows a more balanced profile than related compounds such as (R)-69. [1] [2]