Beta-arrestin-2, also known as arrestin beta-2, is an intracellular
protein that in humans is encoded by the ARRB2gene.
Members of
arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of
G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,[5][6][7] as well as having signalling roles in their own right.[8][9][10][11][12] Arrestin beta 2, like
arrestin beta 1, was shown to inhibit
beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a
cDNA for arrestin beta 2 was isolated from
thyroid gland, and thus it may also be involved in hormone-specific desensitization of
TSH receptors. Multiple
alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[13]
^Patel PA, Tilley DG, Rockman HA (March 2009). "Physiologic and cardiac roles of beta-arrestins". Journal of Molecular and Cellular Cardiology. 46 (3): 300–8.
doi:
10.1016/j.yjmcc.2008.11.015.
PMID19103204.
^Golan M, Schreiber G, Avissar S (2009). "Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functions". Current Pharmaceutical Design. 15 (14): 1699–708.
doi:
10.2174/138161209788168038.
PMID19442183.
Rapoport B, Kaufman KD, Chazenbalk GD (April 1992). "Cloning of a member of the arrestin family from a human thyroid cDNA library". Molecular and Cellular Endocrinology. 84 (3): R39-43.
doi:
10.1016/0303-7207(92)90038-8.
PMID1587386.
S2CID1964362.
Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A (September 1994). "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286–8.
doi:
10.1006/geno.1994.1497.
PMID7695743.
McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ (November 2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science. 290 (5496): 1574–7.
Bibcode:
2000Sci...290.1574M.
doi:
10.1126/science.290.5496.1574.
PMID11090355.
Beta-arrestin-2, also known as arrestin beta-2, is an intracellular
protein that in humans is encoded by the ARRB2gene.
Members of
arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of
G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,[5][6][7] as well as having signalling roles in their own right.[8][9][10][11][12] Arrestin beta 2, like
arrestin beta 1, was shown to inhibit
beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a
cDNA for arrestin beta 2 was isolated from
thyroid gland, and thus it may also be involved in hormone-specific desensitization of
TSH receptors. Multiple
alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[13]
^Patel PA, Tilley DG, Rockman HA (March 2009). "Physiologic and cardiac roles of beta-arrestins". Journal of Molecular and Cellular Cardiology. 46 (3): 300–8.
doi:
10.1016/j.yjmcc.2008.11.015.
PMID19103204.
^Golan M, Schreiber G, Avissar S (2009). "Antidepressants, beta-arrestins and GRKs: from regulation of signal desensitization to intracellular multifunctional adaptor functions". Current Pharmaceutical Design. 15 (14): 1699–708.
doi:
10.2174/138161209788168038.
PMID19442183.
Rapoport B, Kaufman KD, Chazenbalk GD (April 1992). "Cloning of a member of the arrestin family from a human thyroid cDNA library". Molecular and Cellular Endocrinology. 84 (3): R39-43.
doi:
10.1016/0303-7207(92)90038-8.
PMID1587386.
S2CID1964362.
Calabrese G, Sallese M, Stornaiuolo A, Stuppia L, Palka G, De Blasi A (September 1994). "Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes". Genomics. 23 (1): 286–8.
doi:
10.1006/geno.1994.1497.
PMID7695743.
McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ (November 2000). "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3". Science. 290 (5496): 1574–7.
Bibcode:
2000Sci...290.1574M.
doi:
10.1126/science.290.5496.1574.
PMID11090355.