From Wikipedia, the free encyclopedia
MS4A2
Identifiers
Aliases MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDs OMIM: 147138; MGI: 95495; HomoloGene: 112; GeneCards: MS4A2; OMA: MS4A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000139
NM_001142303
NM_001256916

NM_001276328
NM_001276329
NM_001276330
NM_013516

RefSeq (protein)

NP_000130
NP_001243845

NP_001263257
NP_001263258
NP_001263259
NP_038544

Location (UCSC) Chr 11: 60.09 – 60.1 Mb Chr 19: 11.59 – 11.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. [5] [6]

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members. [6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149534Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024680Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett. 302 (2): 161–5. doi: 10.1016/0014-5793(92)80430-O. PMID  1386024. S2CID  44791683.
  6. ^ a b "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



From Wikipedia, the free encyclopedia
MS4A2
Identifiers
Aliases MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDs OMIM: 147138; MGI: 95495; HomoloGene: 112; GeneCards: MS4A2; OMA: MS4A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000139
NM_001142303
NM_001256916

NM_001276328
NM_001276329
NM_001276330
NM_013516

RefSeq (protein)

NP_000130
NP_001243845

NP_001263257
NP_001263258
NP_001263259
NP_038544

Location (UCSC) Chr 11: 60.09 – 60.1 Mb Chr 19: 11.59 – 11.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. [5] [6]

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members. [6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149534Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024680Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett. 302 (2): 161–5. doi: 10.1016/0014-5793(92)80430-O. PMID  1386024. S2CID  44791683.
  6. ^ a b "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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