40S ribosomal protein S3 is a
protein that in humans is encoded by the RPS3gene.[5][6][7]
Function
Ribosomes, the
organelles that
catalyzeprotein synthesis, consist of a
small 40S subunit and a
large 60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the
mouse and
rat proteins have demonstrated that the protein has an extraribosomal role as an
endonuclease involved in the repair of
UV-induced
DNA damage. The protein appears to be located in both the
cytoplasm and
nucleus but not in the
nucleolus. Higher levels of expression of this gene in
colon adenocarcinomas and
adenomatous polyps compared to adjacent normal
colonic mucosa have been observed. This gene is co-transcribed with the
small nucleolar RNA genes
U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple
processed pseudogenes of this gene dispersed through the genome.[7]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Lim Y, Lee SM, Kim M, Lee JY, Moon EP, Lee BJ, Kim J (2002). "Complete genomic structure of human rpS3: identification of functional U15b snoRNA in the fifth intron". Gene. 286 (2): 291–7.
doi:
10.1016/S0378-1119(02)00502-4.
PMID11943484.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.
40S ribosomal protein S3 is a
protein that in humans is encoded by the RPS3gene.[5][6][7]
Function
Ribosomes, the
organelles that
catalyzeprotein synthesis, consist of a
small 40S subunit and a
large 60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the
mouse and
rat proteins have demonstrated that the protein has an extraribosomal role as an
endonuclease involved in the repair of
UV-induced
DNA damage. The protein appears to be located in both the
cytoplasm and
nucleus but not in the
nucleolus. Higher levels of expression of this gene in
colon adenocarcinomas and
adenomatous polyps compared to adjacent normal
colonic mucosa have been observed. This gene is co-transcribed with the
small nucleolar RNA genes
U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple
processed pseudogenes of this gene dispersed through the genome.[7]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Lim Y, Lee SM, Kim M, Lee JY, Moon EP, Lee BJ, Kim J (2002). "Complete genomic structure of human rpS3: identification of functional U15b snoRNA in the fifth intron". Gene. 286 (2): 291–7.
doi:
10.1016/S0378-1119(02)00502-4.
PMID11943484.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105.
doi:
10.1038/ncb1086.
PMID14743216.
S2CID11683986.