60S ribosomal protein L28 is a
protein that in humans is encoded by the RPL28gene.[5][6][7]
Function
Ribosomes, the
organelles that catalyze
protein synthesis, consist of a small
40S subunit and a large
60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 60S subunit. The protein belongs to the
L28E family of ribosomal proteins. It is located in the
cytoplasm. Variable expression of this gene in
colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome.[7]
Kasai H, Nadano D, Hidaka E, et al. (2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74.
doi:
10.1177/002215540305100502.
PMID12704204.
S2CID25865715.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58.
doi:
10.1023/A:1025068419698.
PMID12962325.
S2CID10710245.
60S ribosomal protein L28 is a
protein that in humans is encoded by the RPL28gene.[5][6][7]
Function
Ribosomes, the
organelles that catalyze
protein synthesis, consist of a small
40S subunit and a large
60S subunit. Together these subunits are composed of 4
RNA species and approximately 80 structurally distinct proteins. This gene encodes a
ribosomal protein that is a component of the 60S subunit. The protein belongs to the
L28E family of ribosomal proteins. It is located in the
cytoplasm. Variable expression of this gene in
colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome.[7]
Kasai H, Nadano D, Hidaka E, et al. (2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74.
doi:
10.1177/002215540305100502.
PMID12704204.
S2CID25865715.
Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58.
doi:
10.1023/A:1025068419698.
PMID12962325.
S2CID10710245.