Clinical data | |
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AHFS/ Drugs.com | Micromedex Detailed Consumer Information |
ATC code | |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.020.543 |
Chemical and physical data | |
Formula | C26H28N3+ |
Molar mass | 382.531 g·mol−1 |
3D model ( JSmol) | |
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Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. [1] Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. [2] [3] Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α. [4] [5]
Pyrvinium salts can also inhibit the growth of cancer cells. [6] More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation. [7]
One synthetic method is based on Skraup synthesis and Paal-Knorr synthesis. [6] More recently, an alternative convergent, synthetic strategy to pyrvinium triflate salts through Friedländer synthesis was reported. [3]
{{
cite journal}}
: CS1 maint: DOI inactive as of February 2024 (
link)
Clinical data | |
---|---|
AHFS/ Drugs.com | Micromedex Detailed Consumer Information |
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.020.543 |
Chemical and physical data | |
Formula | C26H28N3+ |
Molar mass | 382.531 g·mol−1 |
3D model ( JSmol) | |
| |
|
Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. [1] Several forms of pyrvinium have been prepared with variable counter anions, such as halides, tosylate, triflate and pamoate. [2] [3] Pyrvinium was identified as a potent Wnt inhibitor, acting through activation of Casein kinase CK1α. [4] [5]
Pyrvinium salts can also inhibit the growth of cancer cells. [6] More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation. [7]
One synthetic method is based on Skraup synthesis and Paal-Knorr synthesis. [6] More recently, an alternative convergent, synthetic strategy to pyrvinium triflate salts through Friedländer synthesis was reported. [3]
{{
cite journal}}
: CS1 maint: DOI inactive as of February 2024 (
link)