Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an
enzyme that in humans is encoded by the PAPSS1gene.[5][6][7]
Three-prime-phosphoadenosine 5-prime-phosphosulfate (
PAPS) is the
sulfate donor cosubstrate for all
sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other
xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and
PAPSS2 (MIM 603005).[supplied by OMIM][7]
^ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62.
doi:
10.1038/2458.
PMID9771708.
S2CID13108930.
Harjes S, Scheidig A, Bayer P (2004). "Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1". Acta Crystallogr. D. 60 (Pt 2): 350–2.
doi:
10.1107/S0907444903027628.
PMID14747722.
Lansdon EB, Fisher AJ, Segel IH (2004). "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains". Biochemistry. 43 (14): 4356–65.
doi:
10.1021/bi049827m.
PMID15065880.
Harjes S, Bayer P, Scheidig AJ (2005). "The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding". J. Mol. Biol. 347 (3): 623–35.
doi:
10.1016/j.jmb.2005.01.005.
PMID15755455.
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an
enzyme that in humans is encoded by the PAPSS1gene.[5][6][7]
Three-prime-phosphoadenosine 5-prime-phosphosulfate (
PAPS) is the
sulfate donor cosubstrate for all
sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other
xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and
PAPSS2 (MIM 603005).[supplied by OMIM][7]
^ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet. 20 (2): 157–62.
doi:
10.1038/2458.
PMID9771708.
S2CID13108930.
Harjes S, Scheidig A, Bayer P (2004). "Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1". Acta Crystallogr. D. 60 (Pt 2): 350–2.
doi:
10.1107/S0907444903027628.
PMID14747722.
Lansdon EB, Fisher AJ, Segel IH (2004). "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains". Biochemistry. 43 (14): 4356–65.
doi:
10.1021/bi049827m.
PMID15065880.
Harjes S, Bayer P, Scheidig AJ (2005). "The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding". J. Mol. Biol. 347 (3): 623–35.
doi:
10.1016/j.jmb.2005.01.005.
PMID15755455.