A non-noradrenergic, non-cholinergic transmitter (NANC) is a neurotransmitter of the enteric nervous system (ENS) that is neither acetylcholine, norepinephrine, nor epinephrine.
This table compares different NANCs in the PNS:
Neurotransmitter | Type | Location [1] | Function [1] |
---|---|---|---|
ATP | non- peptide | postganglionic sympathetic neurons (e.g. in blood vessels & vas deferens) | Fast depolarization/contraction ( vasoconstriction) |
GABA | non- peptide | ENSs | peristalsis |
5-HT | non- peptide | ENSs | peristalsis |
dopamine | non- peptide | some SNSs (e.g. kidney) | vasodilation |
NO | non- peptide | gastric nerves & Pelvic Nerve |
|
NPY | peptide | postganglionic sympathetic neurons (e.g. blood vessels) |
|
VIP | peptide |
|
|
GnRH | peptide | sympathetic ganglia |
|
substance P | peptide |
| |
CGRP | peptide | non- myelinated sensory neurons |
A non-noradrenergic, non-cholinergic transmitter (NANC) is a neurotransmitter of the enteric nervous system (ENS) that is neither acetylcholine, norepinephrine, nor epinephrine.
This table compares different NANCs in the PNS:
Neurotransmitter | Type | Location [1] | Function [1] |
---|---|---|---|
ATP | non- peptide | postganglionic sympathetic neurons (e.g. in blood vessels & vas deferens) | Fast depolarization/contraction ( vasoconstriction) |
GABA | non- peptide | ENSs | peristalsis |
5-HT | non- peptide | ENSs | peristalsis |
dopamine | non- peptide | some SNSs (e.g. kidney) | vasodilation |
NO | non- peptide | gastric nerves & Pelvic Nerve |
|
NPY | peptide | postganglionic sympathetic neurons (e.g. blood vessels) |
|
VIP | peptide |
|
|
GnRH | peptide | sympathetic ganglia |
|
substance P | peptide |
| |
CGRP | peptide | non- myelinated sensory neurons |