From Wikipedia, the free encyclopedia
Nardilysin (
EC
3.4.24.61, N-arginine dibasic convertase, NRD-convertase) is an
enzyme.
[1]
[2]
[3]
[4] This enzyme
catalyses the following
chemical reaction
-
Hydrolysis of
polypeptides, preferably at -Xaa-Arg-Lys-, and less commonly at -Arg-Arg-Xaa-, in which Xaa is not Arg or Lys
This enzyme is present rat
brain and
testis.
-
^ Gomez S, Gluschankof P, Morel A, Cohen P (September 1985).
"The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes". The Journal of Biological Chemistry. 260 (19): 10541–5.
doi:
10.1016/S0021-9258(19)85118-9.
PMID
3897221.
-
^ Gluschankof P, Gomez S, Morel A, Cohen P (July 1987).
"Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex". The Journal of Biological Chemistry. 262 (20): 9615–20.
doi:
10.1016/S0021-9258(18)47978-1.
PMID
2885328.
-
^ Chesneau V, Pierotti AR, Barré N, Créminon C, Tougard C, Cohen P (January 1994).
"Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues". The Journal of Biological Chemistry. 269 (3): 2056–61.
doi:
10.1016/S0021-9258(17)42134-X.
PMID
8294457.
-
^ Pierotti AR, Prat A, Chesneau V, Gaudoux F, Leseney AM, Foulon T, Cohen P (June 1994).
"N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 6078–82.
Bibcode:
1994PNAS...91.6078P.
doi:
10.1073/pnas.91.13.6078.
PMC
44141.
PMID
8016118.
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