A disintegrin and metalloproteinase with thrombospondin motifs 1 is an
enzyme that in humans is encoded by the ADAMTS1gene.[5][6]
Function
This gene encodes a member of the
ADAMTS (a
disintegrin and
metalloproteinase with
thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a
propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a
thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of
C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has
anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of
cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.[6]
Overview of all the structural information available in the
PDB for
UniProt: Q9UHI8 (A disintegrin and metalloproteinase with thrombospondin motifs 1) at the
PDBe-KB.
A disintegrin and metalloproteinase with thrombospondin motifs 1 is an
enzyme that in humans is encoded by the ADAMTS1gene.[5][6]
Function
This gene encodes a member of the
ADAMTS (a
disintegrin and
metalloproteinase with
thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a
propeptide region, a
metalloproteinase domain, a disintegrin-like domain, and a
thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of
C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has
anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of
cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.[6]
Overview of all the structural information available in the
PDB for
UniProt: Q9UHI8 (A disintegrin and metalloproteinase with thrombospondin motifs 1) at the
PDBe-KB.