DBH-like monooxygenase protein 1, also known as monooxygenase X, is an
enzyme that in humans is encoded by the MOXD1gene.[5][6]
DBH-like 1 maintains many of the structural features of dopamine beta-
monooxygenaseDBH.[7] Since Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) is homologous to dopamine beta-monooxygenase (DBM; EC 1.14.17.1)[8] this concerns a structural basis for a new family of
copper type II, significantly specific for ascorbate-dependent monooxygenases[8] based on the corresponding mouse homolog.[6] The pathway of
catecholamine synthesis is a possible catecholamine-binding
metabolic copper[9] enzyme domain, a neuron-like property encoding MOX without a signal sequence enzyme metabolism resolving the
monooxygenase X chemical pathway[9] of an unknown substrate,[6]exogenous MOX is not secreted, and it localizes throughout the
endoplasmic reticulum,[9] in both
endocrine or nonendocrine cells.[9]
Deficiency
DBH deficiency has been treated effectively with L-threo-3,4-dihydroxyphenylserine (
DOPS).[10]
DBH-like monooxygenase protein 1, also known as monooxygenase X, is an
enzyme that in humans is encoded by the MOXD1gene.[5][6]
DBH-like 1 maintains many of the structural features of dopamine beta-
monooxygenaseDBH.[7] Since Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) is homologous to dopamine beta-monooxygenase (DBM; EC 1.14.17.1)[8] this concerns a structural basis for a new family of
copper type II, significantly specific for ascorbate-dependent monooxygenases[8] based on the corresponding mouse homolog.[6] The pathway of
catecholamine synthesis is a possible catecholamine-binding
metabolic copper[9] enzyme domain, a neuron-like property encoding MOX without a signal sequence enzyme metabolism resolving the
monooxygenase X chemical pathway[9] of an unknown substrate,[6]exogenous MOX is not secreted, and it localizes throughout the
endoplasmic reticulum,[9] in both
endocrine or nonendocrine cells.[9]
Deficiency
DBH deficiency has been treated effectively with L-threo-3,4-dihydroxyphenylserine (
DOPS).[10]