The
hypoxia inducible factor (HIF) is a transcriptional complex which is involved in
oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by
prolyl hydroxylation.
This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[5]
McNeill LA, Hewitson KS, Gleadle JM, et al. (2002). "The use of dioxygen by HIF prolyl hydroxylase (PHD1)". Bioorg. Med. Chem. Lett. 12 (12): 1547–50.
doi:
10.1016/S0960-894X(02)00219-6.
PMID12039559.
Oehme F, Ellinghaus P, Kolkhof P, et al. (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343–9.
doi:
10.1016/S0006-291X(02)00862-8.
PMID12163023.
The
hypoxia inducible factor (HIF) is a transcriptional complex which is involved in
oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by
prolyl hydroxylation.
This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[5]
McNeill LA, Hewitson KS, Gleadle JM, et al. (2002). "The use of dioxygen by HIF prolyl hydroxylase (PHD1)". Bioorg. Med. Chem. Lett. 12 (12): 1547–50.
doi:
10.1016/S0960-894X(02)00219-6.
PMID12039559.
Oehme F, Ellinghaus P, Kolkhof P, et al. (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343–9.
doi:
10.1016/S0006-291X(02)00862-8.
PMID12163023.