Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an
enzyme that in humans is encoded by the JMJD6gene.[5][6]
Function
This gene encodes a nuclear protein with a
JmjC domain. JmjC domain-containing proteins belong to the
alpha-ketoglutarate-dependent hydroxylase superfamily. They are predicted to function as protein
hydroxylases or
histonedemethylases. This protein was first identified as a putative
phosphatidylserine receptor involved in
phagocytosis of
apoptotic cells. Subsequent studies suggest that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.[6] On a physiological level JMJD6 has a role in angiogenesis, the process of vessel formation, whereas further roles of JMJD6 in pathophysiological processes were implicated, such as mammary tumorigenesis.[7] Here, elevated JMJD6 level were found in breast cancer associated with aggressiveness and metastasis in mice.[8]
Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L (January 2003). "Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells". Journal of Neurochemistry. 84 (2): 413–6.
doi:
10.1046/j.1471-4159.2003.01562.x.
PMID12559004.
S2CID29957905.
Cui P, Qin B, Liu N, Pan G, Pei D (February 2004). "Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals". Experimental Cell Research. 293 (1): 154–63.
doi:
10.1016/j.yexcr.2003.09.023.
PMID14729065.
Hong JR, Lin GH, Lin CJ, Wang WP, Lee CC, Lin TL, Wu JL (November 2004). "Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish". Development. 131 (21): 5417–27.
doi:
10.1242/dev.01409.
PMID15469976.
S2CID11188261.
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an
enzyme that in humans is encoded by the JMJD6gene.[5][6]
Function
This gene encodes a nuclear protein with a
JmjC domain. JmjC domain-containing proteins belong to the
alpha-ketoglutarate-dependent hydroxylase superfamily. They are predicted to function as protein
hydroxylases or
histonedemethylases. This protein was first identified as a putative
phosphatidylserine receptor involved in
phagocytosis of
apoptotic cells. Subsequent studies suggest that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene.[6] On a physiological level JMJD6 has a role in angiogenesis, the process of vessel formation, whereas further roles of JMJD6 in pathophysiological processes were implicated, such as mammary tumorigenesis.[7] Here, elevated JMJD6 level were found in breast cancer associated with aggressiveness and metastasis in mice.[8]
Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L (January 2003). "Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells". Journal of Neurochemistry. 84 (2): 413–6.
doi:
10.1046/j.1471-4159.2003.01562.x.
PMID12559004.
S2CID29957905.
Cui P, Qin B, Liu N, Pan G, Pei D (February 2004). "Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals". Experimental Cell Research. 293 (1): 154–63.
doi:
10.1016/j.yexcr.2003.09.023.
PMID14729065.
Hong JR, Lin GH, Lin CJ, Wang WP, Lee CC, Lin TL, Wu JL (November 2004). "Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish". Development. 131 (21): 5417–27.
doi:
10.1242/dev.01409.
PMID15469976.
S2CID11188261.