From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a
protein that in humans is encoded by the ITGA8
gene .
[5]
[6]
Schnapp LM, Hatch N, Ramos DM, et al. (1995).
"The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin" . J. Biol. Chem . 270 (39): 23196–202.
doi :
10.1074/jbc.270.39.23196 .
PMID
7559467 .
Denda S, Müller U, Crossin KL, et al. (1998).
"Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C" . Biochemistry . 37 (16): 5464–74.
doi :
10.1021/bi9727489 .
PMC
2710129 .
PMID
9548928 .
Hartner A, Schöcklmann H, Pröls F, et al. (1999).
"Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis" . Kidney Int . 56 (4): 1468–80.
doi :
10.1046/j.1523-1755.1999.00662.x .
PMID
10504498 .
Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1". Nat. Genet . 24 (4): 424–8.
doi :
10.1038/74286 .
PMID
10742111 .
S2CID
2316181 .
Brandenberger R, Schmidt A, Linton J, et al. (2001).
"Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney" . J. Cell Biol . 154 (2): 447–58.
doi :
10.1083/jcb.200103069 .
PMC
2150762 .
PMID
11470831 .
Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001).
"Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas" . J. Histochem. Cytochem . 49 (11): 1341–50.
doi :
10.1177/002215540104901102 .
PMID
11668187 .
Valerius MT, Patterson LT, Feng Y, Potter SS (2002).
"Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney" . Proc. Natl. Acad. Sci. U.S.A . 99 (12): 8090–5.
Bibcode :
2002PNAS...99.8090V .
doi :
10.1073/pnas.122229199 .
PMC
123025 .
PMID
12060755 .
Lu M, Munger JS, Steadele M, et al. (2003).
"Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1" . J. Cell Sci . 115 (Pt 23): 4641–8.
doi :
10.1242/jcs.00145 .
PMID
12415008 .
Bieritz B, Spessotto P, Colombatti A, et al. (2004).
"Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation" . Kidney Int . 64 (1): 119–27.
doi :
10.1046/j.1523-1755.2003.00057.x .
PMID
12787402 .
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004).
"The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81.
Bibcode :
2004Natur.429..375D .
doi :
10.1038/nature02462 .
PMID
15164054 .
Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)". Matrix Biol . 23 (7): 487–96.
doi :
10.1016/j.matbio.2004.08.005 .
PMID
15579315 .
Scherberich A, Tucker RP, Degen M, et al. (2005).
"Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro" . Oncogene . 24 (9): 1525–32.
doi :
10.1038/sj.onc.1208342 .
PMID
15592496 .
Alpha Beta Dimers
Cytoadhesin receptor: Fibrinogen receptor: Fibronectin receptor: Leukocyte-adhesion receptor: Very late antigen receptor: Vitronectin receptor: