Histone deacetylase 5 is an
enzyme that in humans is encoded by the HDAC5gene.[5][6][7]
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters
chromosome structure and affects
transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses
histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.[7]
HDAC5 is involved in
memory consolidation and suggests that development of more selective
HDAC inhibitors for the treatment of
Alzheimer's disease should avoid targeting HDAC5.[9] Its function can be effectively examined by siRNA knockdown based on an independent validation.[10]
HDAC5 overexpression in
urothelial carcinoma cell lines inhibits long-term proliferation but can promote epithelial-to-mesenchymal transition (
EMT)[11]
Interactions
Histone deacetylase 5 has been shown to
interact with:
^Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84.
doi:
10.1038/sj.onc.1206902.
PMID14668799.
S2CID24491249.
Mahlknecht U, Schnittger S, Ottmann OG, Schoch C, Mosebach M, Hiddemann W, Hoelzer D (October 2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (3): 342–8.
doi:
10.1016/S0167-4781(00)00191-3.
PMID11018260.
Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, et al. (October 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116–23.
doi:
10.1182/blood.V98.7.2116.
PMID11567998.
Huang Y, Tan M, Gosink M, Wang KK, Sun Y (May 2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis". Cancer Research. 62 (10): 2913–22.
PMID12019172.
Histone deacetylase 5 is an
enzyme that in humans is encoded by the HDAC5gene.[5][6][7]
Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters
chromosome structure and affects
transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses
histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.[7]
HDAC5 is involved in
memory consolidation and suggests that development of more selective
HDAC inhibitors for the treatment of
Alzheimer's disease should avoid targeting HDAC5.[9] Its function can be effectively examined by siRNA knockdown based on an independent validation.[10]
HDAC5 overexpression in
urothelial carcinoma cell lines inhibits long-term proliferation but can promote epithelial-to-mesenchymal transition (
EMT)[11]
Interactions
Histone deacetylase 5 has been shown to
interact with:
^Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84.
doi:
10.1038/sj.onc.1206902.
PMID14668799.
S2CID24491249.
Mahlknecht U, Schnittger S, Ottmann OG, Schoch C, Mosebach M, Hiddemann W, Hoelzer D (October 2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (3): 342–8.
doi:
10.1016/S0167-4781(00)00191-3.
PMID11018260.
Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, et al. (October 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116–23.
doi:
10.1182/blood.V98.7.2116.
PMID11567998.
Huang Y, Tan M, Gosink M, Wang KK, Sun Y (May 2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis". Cancer Research. 62 (10): 2913–22.
PMID12019172.