| Glycyl endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.22.25 | ||||||||
| CAS no. | 149719-24-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glycyl endopeptidase ( EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya proteinase 4, PPIV, chymopapain M) is an enzyme. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction
- Preferential cleavage: Gly-, in proteins and small molecule substrates
This enzyme is isolated from the papaya plant, Carica papaya.
- ^ Polgár L (April 1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochimica et Biophysica Acta (BBA) - Enzymology. 658 (2): 262–9. doi: 10.1016/0005-2744(81)90296-5. PMID 7018581.
- ^ Buttle DJ, Kembhavi AA, Sharp SL, Shute RE, Rich DH, Barrett AJ (July 1989). "Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex". The Biochemical Journal. 261 (2): 469–76. doi: 10.1042/bj2610469. PMC 1138849. PMID 2505761.
- ^ Ritonja A, Buttle DJ, Rawlings ND, Turk V, Barrett AJ (November 1989). "Papaya proteinase IV amino acid sequence". FEBS Letters. 258 (1): 109–12. doi: 10.1016/0014-5793(89)81627-8. PMID 2591528.
- ^ Buttle DJ, Ritonja A, Pearl LH, Turk V, Barrett AJ (January 1990). "Selective cleavage of glycyl bonds by papaya proteinase IV". FEBS Letters. 260 (2): 195–7. doi: 10.1016/0014-5793(90)80101-n. PMID 2404797.
- ^ Buttle DJ, Ritonja A, Dando PM, Abrahamson M, Shaw EN, Wikstrom P, Turk V, Barrett AJ (March 1990). "Interactions of papaya proteinase IV with inhibitors". FEBS Letters. 262 (1): 58–60. doi: 10.1016/0014-5793(90)80153-a. PMID 1690669.
- Glycyl+endopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
| Glycyl endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.22.25 | ||||||||
| CAS no. | 149719-24-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glycyl endopeptidase ( EC 3.4.22.25, papaya peptidase B, papaya proteinase IV, glycine-specific proteinase, chymopapain, Papaya proteinase 4, PPIV, chymopapain M) is an enzyme. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction
- Preferential cleavage: Gly-, in proteins and small molecule substrates
This enzyme is isolated from the papaya plant, Carica papaya.
- ^ Polgár L (April 1981). "Isolation of highly active papaya peptidases A and B from commercial chymopapain". Biochimica et Biophysica Acta (BBA) - Enzymology. 658 (2): 262–9. doi: 10.1016/0005-2744(81)90296-5. PMID 7018581.
- ^ Buttle DJ, Kembhavi AA, Sharp SL, Shute RE, Rich DH, Barrett AJ (July 1989). "Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex". The Biochemical Journal. 261 (2): 469–76. doi: 10.1042/bj2610469. PMC 1138849. PMID 2505761.
- ^ Ritonja A, Buttle DJ, Rawlings ND, Turk V, Barrett AJ (November 1989). "Papaya proteinase IV amino acid sequence". FEBS Letters. 258 (1): 109–12. doi: 10.1016/0014-5793(89)81627-8. PMID 2591528.
- ^ Buttle DJ, Ritonja A, Pearl LH, Turk V, Barrett AJ (January 1990). "Selective cleavage of glycyl bonds by papaya proteinase IV". FEBS Letters. 260 (2): 195–7. doi: 10.1016/0014-5793(90)80101-n. PMID 2404797.
- ^ Buttle DJ, Ritonja A, Dando PM, Abrahamson M, Shaw EN, Wikstrom P, Turk V, Barrett AJ (March 1990). "Interactions of papaya proteinase IV with inhibitors". FEBS Letters. 262 (1): 58–60. doi: 10.1016/0014-5793(90)80153-a. PMID 1690669.
- Glycyl+endopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)